Chapter 23-27-28 Flashcards
Nucleic acid can be
DNA or RNA ; circular or linear; single or double stranded
Nucleic Acid core surround by capsid (protein cover: repeats of 1 to a few proteins)
No cytoplasm
Some virus also have an envelop ( lipids + protein)
Structures of virus
Virus are classified by their genome
DNA viruses
RNA viruses
Retroviruses ( genes encoded by RNA but include DNA intermediates in those replication)
Virion
Name that recieve the viruses when they are outside of a cell, then they are metabolically inert
Virus hijacks
A cells transcription and translation machine ties to express genes needed to make additional copies of the virus… The virus tricks host cell into making viruses
Bacteriophage
Virus that affects bacteria
Attachment: Virus only attacks
CD4+ cells, viral gp120 glycoproteins attaches to CD4 protein on macrophages and Cd4 cells . Correceptors like CCR5 protein affect likelihood of entry located on cd4 surface. People with a mitigation for the protein are resistant
Replication: Reverse transcriptase
Converts virus RNA to double stranded DNA
Enzyme is extremely error prone
Mutations common in the process
Assembly:
Making copies of virus
Release:
New viruses exit by budding
Aid treatment targets 4
Viral entry
Genome replication
Intervention of viral DNA
Maturation of HIV proteins
Combination theory
Use combination of drugs to lower death rate
Prokaryotes
Oldest, structurally simplest, and most abundant forms of life and fall into two domains bacteria and archae
Molecular classification of prokaryotes
- Amino acid sequences of key proteins
- Percent guanine-cytosine content
- Nucleic acid hybridization (closely related species will have more base pairing)
- Gene and RNA sequencing
Especially RNA - Whole genome sequencing
Characteristics of prokaryotes
1) Unicellularity and variable is size
2) chromosome
3) cell division: binary fission
4) single replication origin mechanism
5) genetic recombination
6) no internal compartmentalization
7) cell walls different layers
8) flagella simple
9) metabolic diversity: photo and chemosynthesis