Chapter 21 Flashcards
Axonal neuropathy
• Direct injury to axon
Wallerian degeneration (destroy axon and myelin degrades)
↓ amplitude
Demyelinating neuropathy
• Damage to SCHWANN cells or myelin SPARES AXON
random internode demyelination
slowed nerve conduction velocity
Mononeuropathy
asymmetric
• Entrapment: carpal tunnel syndrome = thenar atrophy
• Trauma: shoulder dislocation = axillary nerve palsy
Polyneuropathy
symmetric axonal loss
• ‘stocking and glove’ paresthesia/anesthesia
• Diabetics, alcoholism
Polyneuritis multiplex
randomly affects portions of individual nerves
• Autoimmune: RA wrist drop, polyarteritis nodosa
Guillain—Barre Syndrome
- acute motor neuron demyelination –>ASCENDING paralysis; respiratory failure possible
- Autoimmune: idiopathic –>viral
- Males
- Ages 15-35 or 50-57
- Ventilation
Chronic Inflammatory Demyelinating Polyneuropathy
CIDP
• Relapsing chronic GBS onion-skin Schwann cells • associated with immune disorders: lupus, HIV • Males (2x) • 40-60 (older) • MC some residual LOF
Diabetic Peripheral neuropathy
• #1 cause of peripheral neuropathy, 50% of DM
↓ sensation: distal, symmetric
what/how do environmental toxins injure peripheral nerves
- Alter axonal transport or cytoskeletal damage
- ADRs, lead, methyl-mercury
- Longest neurons
what genetic condition injures peripheral nerves
- PMP22 gene mutation
- Charcot-Marie-Tooth disease
- Axonal or demyelinating, motor & sensory
- Pes cavus
Myasthenia gravis
NMJ disorder degrade post-synaptic Ach receptors • Extraocular weakness worse w e-stim • Females (MC): 20-30 years
Lambert-Eaton Syndrome
NMJ disorder • Auto-antibodies inhibit PRE-SYNAPTIC Ca++ channels • Repetitive e-stimulation improves • Females MC • 60 years
Congenital myasthenic syndromes
- Mutations alter NMJ proteins pre/post/synaptic
* Mimic MG or LES few respond to AChase inhibitors
what infections effect NMJs?
- Clostridium tetani: ↑ACh release
* Clostridium botulinum: ↓ACh release; DESCENDING paralysis
what causes ascending paralysis?
descending paralysis?
ascending- GBS
descending- botulism