chapter 20 (bones, joints, and soft tissue tumors) Flashcards

0
Q

a developmental anomaly of bone is referred to generally as?

A

Dysostosis

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1
Q

what tissues make-up the musculoskeletal system

A

osseous, muscular and connective tissue

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2
Q

what is the most common defective ossification associated with dysostosis?

A

fetal cartilage

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3
Q

the structural development during embryologic development is known as?

A

Homeobox gene

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4
Q

what is Aplasia

A

absent or incomplete development (abnormal function)

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5
Q

aplasia, supernumerary digits and abnormal fusion of bones are all examples of ?

A

dysostosis

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6
Q

the interference with growth or homeostasis is referred to in general as?

A

dysplasia

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7
Q

dysplaisa can effect what type of tissues

A

bone and cartilage

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8
Q

what is the AKA for osteogenesis imperfectia

A

brittle bone disease

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9
Q

what is the most common inherited connective tissue disorder

A

osteogenesis imperfecta

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10
Q

what is osteogenesis imperfecta

A

mutations of Type -1 collagen

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11
Q

what will osteogenesis imperfecta cause

A

abnormal structure –> premature breakdown

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12
Q

fractures, extremity bowing, scoliosis, and ligamentous laxity are all symptoms of ?

A

osteogenesis imperfecta

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13
Q

what is the most common form or dwarfism

A

Achondroplasia

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14
Q

shortening of proximal extremities, bowing of legs, frontal bossing, mid-face hypoplasia are all symptoms of ?

A

Achondroplasia

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15
Q

achondroplasia has spontaneous point mutations in what percent of individuals?

16
Q

what is excessive rounding of the frontal bone

A

frontal bossing

17
Q

what bones are most effected by Achondroplasia

A

Femur and humerus

18
Q

what type of osteogenesis imperfecta has a normal lifespan and is autosomal dominant

19
Q

spinal involvement of Achondroplasia will have what type of curves

A

hyperlordosis and hyperkyphosis

20
Q

bullet vertebrae, scoliosis, and central canal stenosis are all symptoms of what congenital disorder

A

Achondroplasia

21
Q

extremely small thorax, shortened long bones, and perinatal respiratory failure are associated with what form of Achondroplasia

A

Thanatophoric dwarfism

22
Q

what can thanatrophoric dwarfism be mistake as

A

osteogenesis imperfecta type II

23
Q

what is a group of rare genetic disorders that have decreased osteoclast-mediated bone resorption

A

osteopetrosis

24
what congenital disorder has skeletal sclerosis aka "stone-like" bone causing and increase risk of fractures
osteopetrosis
25
radiologically those with achondroplasia may present with what finding
Trident hand
26
bright white bone, no medullary cavity and erlenmeyer flask deformity is characteristic of what disease
osteopetrosis
27
what is the general term for loss of bone density
osteopenia