Chapter 16 - Death and Dying Flashcards
Biological Death
hard to define because it is not a single event but a complex process
Different systems of the body die at different rates
total brain death
An irreversible loss of functioning in the entire brain, both the higher centers of the cerebral cortex that are involved in thought and the lower centers of the brain that control basic life processes such as breathing.
Determining total brain death requires extensive testing following specific guidelines that differ some from state to state in the United States
Comas - total brain death
A person in a coma must be observed to be totally unresponsive to stimuli, show no movement in response to noxious stimuli, and have no reflexes such as a constriction of the eye’s pupils in response to light
An electroencephalogram (EEG) or other measures should indicate an absence of electrical activity in the cortex of the brain
This definition means that a coma patient whose heart and lungs are kept going only through artificial means such as a mechanical ventilator but who has no sign of functioning in the brain stem is dead.
Euthanasia
Literally, “good death”; specifically, hastening, either actively or passively, the death of someone suffering from an incurable illness or injury.
Active euthanasia
“mercy killing,” is deliberately and directly causing a person’s death—for example, by administering a lethal dose of drugs to a pain-racked patient in the late stages of cancer or smothering a spouse who has advanced Alzheimer’s disease
Passive euthanasia
by contrast, means allowing a terminally ill person to die of natural causes—for example, by withholding extraordinary life-saving treatments (as when Terri Schiavo’s feeding tube was removed)
assisted suicide
Making available to individuals who wish to commit suicide the means by which they may do so, such as when a physician provides a terminally ill patient who wants to die with enough medication to overdose
Surveys tell us that there is overwhelming support among medical personnel and members of the general public for ____________ euthanasia
passive
Who tends to be more supporting of the right to end life?
Attitudes tend to be most accepting among younger generations, men, and highly educated respondents
Who tends to be less accepting of the right to end life?
African Americans and other minority group members tend to be less accepting of actions to hasten death than European Americans, whether because they do not trust the medical establishment or for religious or philosophical reasons
the law and active euthanasia
still treated as murder in the United States and most countries
the law and passive euthanasia
it is legal to withhold or withdraw extraordinary life-extending treatments from terminally ill patients when that is the wish of the dying person or when the immediate family can show that the individual had expressed a desire to reject life-support measures
living will
A document, also called an advance directive, in which people state in advance that they do not wish to have extraordinary medical procedures applied if they are hopelessly ill.
First state to legalize physician-assisted suicide
Oregon became the first state in the United States to legalize physician-assisted suicide - as patients in European countries such as the Netherlands, Belgium, Luxembourg, and Switzerland can do (when they have 6 or fewer months to live)
denial of death
Since the late 19th century, Ariès argues, Western societies have engaged in a “denial of death.” - taken out of the home and put it in the hospital and funeral home to be managed by physicians and funeral directors; as a result, we have less direct experience with it than our ancestors did
Is there a universal emotional response to death across cultures?
sadness is a common response, but there are no universal emotional responses to death
average life expectancy for a newborn in the United States now?
in 1900?
males now?
females now?
almost 79 years
compared with 47 years in 1900
—76 for males, 81 for females
Why do females tend to have longer lives?
Female hormones seem to protect women from high blood pressure and heart problems, and they are less exposed than men to violent deaths and accidents and to health hazards such as smoking and drinking
Which ethnic group has the highest life expectancy in the US? Lowest?
highest for Hispanics, medium for non-Hispanic whites, and lowest for African Americans
What is the average rate of infant mortality?
dropped to six out of 1,000 live births
During which period of life do we have the lowest chance of dying?
dying during childhood or adolescence
Main causes of infant mortality
mainly associated with congenital abnormalities that infants bring with them to life, low birth weight or short gestation, and complications of pregnancy
Main causes of childhood death
leading cause of death among preschool and school-age children is unintentional injuries or accidents (especially car accidents but also poisonings, falls, fires, drownings, and so on)
Main causes of death of adolescent/emerging adult
Accidents (especially car accidents), suicides, and homicides are the leading killers
Main causes of adult deaths
Accidents continue to kill young adults, but cancers and heart diseases also begin to take a toll
45–54 age group, cancers have become the leading cause of death, followed by heart diseases, which then competes with cancer for the top spot thereafter, with chronic lower respiratory diseases often in third place - These and other chronic illnesses become more likely causes of death as age increases
adults age 65 and older, heart diseases lead the list, followed by cancers and chronic respiratory diseases
Two main categories of theories of aging/dying
programmed theories
damage theories
programmed theories
emphasize the systematic genetic control of aging processes
assume that aging will unfold according to a species-specific genetic program - a predictable genetic timetable
maximum life span - what is it? what is it for humans?
A ceiling on the number of years that any member of a species lives; 120 years for humans. (Among land mammals, humans have the longest maximum life span, estimated at around 125 years) - the maximum life span has changed very little over the past century
Genetic differences account for how much variation among us in age at death
about a third
a fairly good way to estimate how long you will live is to average the longevity of…
your parents and grandparents
Leonard Hayflick
discovered that cells from human embryos could divide only a certain number of times
Hayflick limit
The estimate that human cells can double/divide only 50 times, plus or minus 10, and then will die.
the maximum life span of a species is related to the Hayflick limit for that species: The long-lived Galapagos tortoise’s cells can divide _____ times whereas the cells of the short-lived fruit fly can divide far less than this
90–125
Telomeres
A stretch of DNA that forms the tip of a chromosome and that shortens after each cell division, serving as an aging clock and timing the death of cells
the mechanism behind the “cellular aging clock” suggested by the Hayflick limit on cell division
telomere length is a yardstick of…
biological age
What determines how long your telomeres are?
both genes and environment
differences in telomere length at birth that are partly genetic in origin but can also be influenced by the prenatal environment
chronic stress later in life is linked to shorter-than-average telomeres
shorter telomeres are associated with diseases of aging such as heart disease and diabetes, as well as with psychological disorders such as depression and anxiety
lack of exercise, smoking, obesity, and low socioeconomic status (SES)—all risk factors for age-related diseases—are also associated with short telomeres
Epigenetic aging clock
A measure of patterns of DNA methylation that are closely associated with aging
Based on analysis of DNA methylation patterns, a person’s biological age can be estimated
What influences a person’s epigenetic aging clock?
highly genetically influenced and can also be affected by environmental risk factors such as stress, unhealthy lifestyles, and low SES
Having an epigenetic biological age that is greater than one’s chronological age turns out to be correlated with a number of environmental risk factors known to be associated with chronic diseases of aging, including cardiovascular disease and Alzheimer’s disease
Damage Theories
generally propose that wear and tear—an accumulation of random damage to cells and organs over the years—ultimately causes death
maintain that biological aging is more about random damage than genetically programmed change
Free radicals
a damage theory
Chemically unstable byproducts of metabolism that have an unpaired electron and react with other molecules to produce toxic substances that damage cells and contribute to aging.
toxic and chemically unstable by-products of metabolism, or everyday chemical reactions in cells such as those involved in the breakdown of food - produced when oxygen reacts with certain molecules in the cells
They have an unpaired, or “free,” electron and are highly reactive with and damaging to other molecules in the body, including DNA
Meanwhile, the body’s mechanisms for repairing genetic and epigenetic damage are also becoming more impaired with age and cannot keep up with the chaos - causes aging and eventual death
a visible sign of the damage that can result from free radicals
Age spots
free radicals have also been implicated in which of the major diseases that become more common with age
cardiovascular diseases, cancer, and Alzheimer’s disease
what is the damage of most concern from free radicals?
damage to DNA because the result is more defective cells replicating themselves
Antioxidants
such as vitamins E and C (or foods high in them such as raisins, spinach, and blueberries) or resveratrol (a natural substance in grapes, red wine, and peanuts)
can donate one of their electrons to chemically unstable free radicals, thereby reducing their damage to the body
what casts doubt on the value of the free radical theory as a major explanation of basic aging?
While antioxidants can promote healthier aging with less frailty in later life, they do little to actually lengthen life
A technique demonstrated to extend the life span of laboratory animals
a highly nutritious but severely calorie-restricted diet
caloric restriction reducing intake by 30–40% extends both the average longevity and the maximum life span of a species and that it delays or slows the progression of many age-related diseases
reduces the number of free radicals and other toxic products of metabolism - also appears to alter gene expression and trigger the release of hormones that slow metabolism and therefore decrease oxidative damage
KÜBLER-ROSS’ STAGES OF DYING
denial
anger
bargaining
depression
acceptance
Kübler-Ross emphasized a sixth response that runs throughout the stages:
hope. She believed that it is essential for terminally ill patients to retain some sense of hope, even if it is only the hope that they can die with dignity
four problems with the Kübler-Ross stages
emotional responses to dying are not stagelike
the nature and course of an illness affects reactions to it
individuals differ widely in their responses
dying people focus on living, not just dying
terminal decline
Many dying patients display symptoms of depression and other signs of decreased well-being as part of a deterioration in functioning and emotional well-being shortly before death
Bereavement
A state of loss that provides the occasion for grief and mourning
Grief
The emotional response to loss.