Chapter 15 Microbial Mechanisms of Pathogenicity Flashcards
The ability to cause disease
Pathogenicity
The degree of pathogenicity
Virulence
What are the different portals of entry?
Mucous membranes
Skin
Parenteral Route
Infectious does for 50% of a sample population and measures the virulence of a microbe
ID50
A lethal dose for 50% of a sample population and measures potency of a toxin
LD50
What is the process of adherence?
when pathogens attach to host tissues
Bind to receptors on the host cells
Adhesins (ligands)
Streptococcus pneumonia
pneumonia
Haemophilu influenza
pneumonia and meningitis
Bacillus anthraces
anthrax
Yersinia pestis
plague
Examples of adhesins
Glycocalyx, fimbraiae
Has a glycocalyx around the cell wall
Capsules
Is able to resist phagocytosis
M protein (s. pyogenes)
A protein that allows attachment to host cells
Opa (n. gonorrheae)