Chapter 15: Autonomic Nervous System Flashcards
motor division of the peripheral nervous system can be divided into
Somatic NS and Autonomic NS (ANS).
Autonomic NS (ANS).
also called the involuntary NS and is key in maintaining homeostasis.
It helps control various glands as well as smooth and cardiac muscle, usually without us being aware of it
Somatic motor pathway:
- Motor neuron cell bodies are in CNS.
* Axons extend to skeletal muscles via cranial or spinal nerves.
Autonomic motor pathway:
Involves 2 neurons in sequence.
•First neuron has its cell body located in brainstem or spinal cord
- It is called preganglionic.
- It terminates in a ganglion, where it synapses with the second neuron.
• Second neuron has its cell body located in a ganglion outside the CNS.
- It’s called postganglionic.
- It terminates in an effector organ.
ANS Divisions
i) Sympathetic (SNS)
ii) Parasympathetic (PNS)
The divisions of the ANS differ in:
1) Location of neurons/ganglia
2) Neurotransmitters used
3) Effects on target organs
4) Receptors used
SNS v. PNS: Location of neurons/ganglia
• The preganglionic cell bodies originate in different regions of the spinal cord:
SNS: thoracic and lumbar regions.
PNS: brainstem & sacral regions.
• The ganglia are also found in different areas:
SNS: close to spinal cord.
PNS: in wall of target organ.
- As a result, the SNS has short preganglionic fibers, and long postganglionic fibers.
- The PNS has long preganglionic fibers, and short postganglionic fibers.
SNS v. PNS: Neurotransmitters used
• The preganglionic neurons of both divisions release acetylcholine (ACh).
• The postganglionic neurons differ:
SNS: most postganglionic neurons release norepinephrine (NE).
PNS: postganglionic neurons release ACh.
SNS v. PNS: Effects on target organs
- Often their actions are antagonistic. (e.g. heart)
- Occasionally their actions can be complimentary. (e.g. sexual function)
SNS
- Called the “flight or fight” division.
- Is dominant during vigorous activity.
PNS
- Called the “rest and digest” division.
- Is dominant during resting periods.
SNS v. PNS: Receptors used
SNS
- Targets have “adrenergic” receptors.
- Response depends on type present: α or β-receptors.
PNS
- Targets have “cholinergic” receptors.
- Two types:
i) Nicotinic (all postganglionic neurons)
ii) Muscarinic (all PNS target organs)
ANS Disorders: Hypertension
high blood pressure, over active vasoconstriction response, heart works harder, causes more wear and tear on walls
ANS Disorders: Raynaud’s disease
intermittent attacks causing skin on fingers and toes turn blue and painful. Blood vessels being constricted more than they should so not enough blood getting to fingers, tigered by cold or emotional stress
ANS Disorders: Autonomic dysreflexia
life-threatening, uncontrolled activation of autonoetic neurons. Triggered by painful stimulus to skin or overfilled organ like bladder. Arterial blood pressure skyrockets and can lead to blood vessel bursting in brain leading to stroke. Tends to happen in 1st year after spinal injury or in quadriplegics.