Chapter 14 - Wound Healing Flashcards
This is the first stage of Wound Healing. Days? Cells?
Inflammation; Days 1-10; PMNs, Macrophages; Epithelialization at 1-2mm/day
This is the second stage of wound healing. Days? cells?
Proliferation; 5 days-3 weeks;
Fibroblasts
-neovascularization,
-production of collagen and granulation tissue
This is the third stage of wound healing. Days? what happens?
Remodeling; 3 weeks to 1 year
- Type III collagen replaced with type I
- Net amount of collagen does not change
- Collagen cross linking occurs
At what pace do peripheral nerves regenerate?
1mm/day
The order of cell arrival in a wound:
- Platelets
- PMNs
- Macrophages
- Fibroblasts
- Lymphocytes
What do macrophages do in wound healing?
essential for wound healing
-release growth factors, cytokines, etc.
What do fibroblasts do in wound healing?
replace fibronectin-fibrin with collagen
What does fibronectin do in wound healing?
Chemotactic for macrophages; anchors fibroblasts.
What does Thrombin and Fibrin do in wound healing?
act as growh factors for endothelial cells and fibroblasts.
These are the primary cells in days 0-2
PMN’s
These are the primary cells in days 3-4
Macrophages
These are the primary cells in days 5 and on
Fibroblasts
What makes up the platelet plug?
Platelets and Fibrin
What makes up the provisional Matrix?
platelets, Fibrin, Fibronectin
What is meant by accelerated wound healing?
Reopening of a wound results in quicker healing the 2nd time, as cells are already present
Platelet Alpha granules contain what?
- Platelet Factor 4- aggregation
- Beta Thrombomodulin- binds thrombin
- PDGF - chemoattractant
Dense Granules of platelets contain what?
- Adenosine
- Serotonin
- Calcium
Platelet Aggregation factors include what?
- TXA2
- Thrombin
- Platelet factor 4
Where is platelet activating factor released from?
Platelets
Where is transforming growth factor-alpha released from?
platelets
Where is fibroblast growth factor released from?
Platelets
Where is Beta Lysin released from and what does it do?
Platelets; antimicrobial
Where is PGE2 and PGI2 released from and what do they do?
Platelets; Vasodilator
Where is PGF2 released from? what does it do?
Platelets; Vasoconstriction
What is the most important fact in healing open wounds (secondary intention)?
Epithelial integrity; migration from wound edges, sweat glands, hair follicles
-dependent on granulation tissue
Unepithelialized wounds leak what and promote what?
Leak serum and protein, promote bacteria