Chapter 14 - Lymphoid Tissue Disorders

Question 1

t(14;18) is seen in …

Answer 1

FL

Question 2

Which WBC disorders can progress to DLBCL?

Answer 2

1. CLL

2. FL

Question 3

t(11;14). Where?

Answer 3

Mantle cell lymphoma

Question 4

2 WBC disorders that I have overexpression of Cyclin D1 protein.

Answer 4

1. HCL

2. Mantle cell lymphoma

Question 5

t(8;14) is seen in … . And what is the result?

Answer 5

Burkitt Lymphoma.

Results in overexpression of c-myc (oncogene that promotes cell growth)

Question 6

Which is the MC NHL?

Answer 6

DLBCL

Question 7

Gimme the B symptoms

Answer 7

1. Fever
2. Chills
3. Night sweats

Question 8

CD markers for Reed-Sternberg cells in HL

Answer 8

1. CD15+
2. CD30+
3. CD20-

Question 9

Type of HL, associated with HIV+

Answer 9

Lymphocyte-depleted type.

Question 10

In mixed cellularity type of HL, RS cells produce … and attract eosinophils.

Answer 10

IL-5

Question 11

Which is the MC primary malignancy of bone?

Answer 11

MM

Question 12

M spike in MM, is due to Ig.. or Ig..

Answer 12

IgG (MC) or IgA

Question 13

In Waldenstrom Macroglobulinemia, M spike is due to Ig..

Answer 13

IgM

Question 14

Where are derived Langerhans histiocytes from?

Answer 14

BM monocytes

Question 15

Immunochemistry in Langerhans histiocytosis. (2)

Answer 15

1. CD1a+

2. S100+