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Principles Of Respiratory Care II > Chapter 12 - Non-steroidal Antiasthma Meds > Flashcards

Chapter 12 - Non-steroidal Antiasthma Meds Flashcards

1
Q

What is step 2 asthma?

A

Having episodes more than or equal to 2 times a week

Night episodes more than or equal to 2 times a month

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2
Q

What is step 3 asthma?

A

Has daily asthma attacks

Uses Saba regularly

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3
Q

What is step 1 asthma?

A

Having episodes less than or equal to 2 times a week

Night episodes less than or equal to 2 times a month

Only has exercise induced asthma

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4
Q

Arachidonic acid is a precursor to what?

A

Leukotrienes and prostaglandins

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5
Q

Where Do leukotrienes and other lipid mediators come from?

A

They are not preformed and stored in cells but are made after stimulus activates phospholipase.

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6
Q

What are the two main pathways for lipid mediators from aranchidonic acid?

A

Cyclicoxygenase (COX)

5-LO

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7
Q

What do Cox pathways produce?

A

Prostaglandins and thromboxane

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8
Q

What do 5-Lo pathways produce?

A

Leukotrienes

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9
Q

What is the mode of action for zyflo?

A

5-Lo inhibitor

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10
Q

What are the modes of action for zafirlukast and montelukast?

A

CysLT receptor block

Cysteinyl leukotriene receptor

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11
Q

What triggers are antileukotrienes useful at protecting against?

A

Exercise induced asthma
Asprin induced asthma

Lesser extent (allergen)

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12
Q

What is the use of Antileukotrienes in chronic mild to severe asthma?

2 answers (moderate to severe and mild to moderate)

A

In mild to moderate asthma, it can improve lung function and reduce need for rescue drugs

In moderate to severe
Use with corticosteroids as a additive effect is the basis for asthma control

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13
Q

Asthma guidelines agree that

________ are the most effective for anti inflammatory in asthma.

A

Corticosteroids

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14
Q

What is the use for antileukotrienes in persistent asthma?

A

It may not be optimal as a monotherapy

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15
Q

What drug is a monoclonal antibody?

A

Omalizumab

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16
Q

What is the mode of action for monoclonal antibody’s?

A

Blocks the binding of IGE to IGE receptors on the surface of mast cells and basophils

17
Q

Are you allowed to eat food with accolate?

A

No it should be one hour before meal or two hours after

18
Q

What is the mast cell stabilizing agent?

A

Cromolyn sodium

19
Q

Cromolyn sodium is best at preventing what during an asthmatic episode?

A

Late phase responses like submucosal edema, mucus, hyperactivity

20
Q

What are the three components of asthma?

A

H A P
hyperactivity

Acute asthma attack

Persistent inflammation

21
Q

What group of drugs are used as relievers in asthma?

A

SABA

systemic corticosteroids

Inhaled anticholinergics

22
Q

What group of drugs are used as controllers in relief of asthma?

A

corticosteroids

Nonsteroidal anti-asthma agents

LABA

Theophylline

Principles Of Respiratory Care II (10 decks)

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