Chapter 11 DNA, RNA, and Mutations Flashcards

1
Q
A

Purine

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2
Q
A

Pyrimidine

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3
Q

DNA

A

is the molecule in our cells that stores and directs information responsible for cell growth and reproduction. Found in the nucleus of the cell, contains genetic information in what is called the genome

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4
Q
A

Ribose

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5
Q
A

Deoxyribose

No oxygen is bonded to the carbon

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6
Q
A

Adenosine

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7
Q
A

Thymine

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8
Q
A

Uridine

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9
Q
A

Cytosine

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10
Q
A

Guanine

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11
Q

Nucleotide

A

is comprised of three parts:

  1. A base
  2. A sugar
  3. A phosphate
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12
Q

Pentose Sugars

A

Ribose and Deoxyribose

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13
Q

Phosphate

A

The phosphate makes the backbone of DNA and RNA’s structure.

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14
Q

Nucleoside

A

A nucleotide without a phosphate

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15
Q

Hydrogen Bonding

A

Hydrogen bonds are weak interactions between polar hydrogens (slightly positive charge) and other polar atoms (slightly negative charge)

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16
Q

Cohesion

A

is hydrogen bonding that occurs exclusively between water molecules

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17
Q

Adhesion

A

is hydrogen bonding that occurs when water hydrogen bonds to something that isn’t also water.

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18
Q

Original strand of DNA

Complementary strand of DNA

A

5’–>3’

3’–>5’

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19
Q

DNA Polymerase

A

Enzyme used to duplicate DNA

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20
Q

AMP

A

Adenosine Monophosphate

21
Q

GMP

A

Guanosine Monophosphate

22
Q

CMP

A

Cytidine Monophosphate

23
Q

UMP

A

Uridine Monophosphate

24
Q

Mutation

A

Changes in your DNA

25
Silent Mutation
No change in protein sequence Change in protein sequence but not protein function
26
Visible Mutation
Change in protein sequence and protein function
27
What causes mutations?
Environmental factors: 1. mutagens 1. Nitrosamine (some bacons) 2. Viruses 2. carcinogens
28
What are the requirements for life?
1. Genetic Material (DNA or RNA) 2. Respond to changes in the environment 3. Reproduce 4. Metabolism
29
Viruses Lack
Metabolism
30
Parts of Viruses:
Protein spikes Capsid Envelope
31
Protein spikes
function is to poke a hole into the host cell so that the genetic information can then enter.
32
Capsid
protein that encloses the genetic material.
33
Envelope
additional protein coat that a virus may or may not have.
34
Vaccines
are deactivated viruses. They are the shell (capsid and envelope) or partial shell of a vaccine and do not contain any of the genetic information of the virus. Vaccines are used to teach your body how to create antibodies, so that if it comes into contact with the real thing, it has a working defense.
35
Steps of Viral Infection
After a virus attaches to the host, it injects its viral DNA and uses the host nucleic acids, enzymes, amino acid, and ribosome to make viral mRNA, new viral DNA, and viral proteins. The newly assembled viruses are released to infect other cells.
36
Central dogma
is an idea that DNA is an informational storage molecule capable of replicating itself. Then, the informations had to be read by a manufacturing body within a cell which puts amino acid together in a specific sequence ultimately synthesizing proteins
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Central Dogma Part two:
DNA serves as a template for the direct synthesis of a messenger RNA molecule, in a process known as transcription. Secondly, mRNA is read at a ribosome by a transfer RNA, which work together to assemble specific chain of amino acid, which collectively assemble to generate a protein, in a process known as translation.
38
Substitution
that exchanges one base for another. Could change a codon to one that encodes a different amino acid and cause a small change in the protein function.
39
Deletion
Any number of nucleotides found in the sequence of DNA is lost during DNA replication.
40
Insertion
is the addition of one or more nucleotide base pairs into a DNA sequence, changing the protein function
41
Frameshift Mutation
is a genetic mutation caused by a deletion or insertion of a nucleotide in a DNA sequence that shifts the way the sequence is read.
42
Point mutation
is a genetic mutation where a single nucleotide base is changed.
43
Real world applications of viruses
Therapeutic Agriculture
44
Therapeutic
It’s possible to use a retrovirus as a vector for gene therapy. Since retroviruses integrate their DNA into the host cell, if you could prepare a retrovirus with a proper gene, you could replace a damaged gene with the proper one.
45
Phage therapy
uses these viruses to target bacteria exclusively in cases where a bacterium has grown resistant to antibiotics.
46
Agriculture
Viruses can be used to genetically modify foods. They can delayed fruit ripening for longer shelf life during transportation. Enhanced flavor and nutritional content. Edible vaccines to prevent widespread diseases in developing countries
47
golden rice
It was genetically modified to produce large quantities of vitamin A.
48
Codon
A set of three nucleotide on mRNA
49
Anticodon
A set of 3 nucleotide compliment to the codon located in the tRNA (in the bottom loop)