Chapter 10: Angiogenesis (Secondary Details) Flashcards
True/false: Tumor cells can induce/recruit non-transformed cells that express/secrete pro-angiogenic molecules.
True!
What are the four steps of leading to angiogenesis?
- Vasculogenesis
- Vascular remodeling
- Arteriogenesis
- Angiogenesis
What is vasculogenesis?
Formation of blood vessels de novo from precursor cells (angioblasts)
What is vascular remodeling?
Adaptation and maturation of (primitive) blood vessels
What is arteriogenesis?
Increase in diameter of existing arterial vessels
What are the diverse functions of endothelial cells?
- Transport of molecules over the vessel wall.
- Initiation/regulation of the clotting system.
- Selection of the white blood cells forming the leukocyte infiltrate.
- Formation of new blood vessel - angiogenesis
True/false: Tumor cells secrete soluble factors to induce angiogenesis
True
True/false: The importance of angiogenesis was only recently discovered (~2000)
False, it was already discovered in the 1971
Is VEGF-A a homodimer or a heterodimer?
Homodimer (it’s a homodimeric heparin-binding glycoprotein)
There are three different VEGF-receptors and five different VEGF families. What are the different ‘physiological effect’ upon binding of the different combinations?
Haematopoiesis, vasculogenesis, angiogenesis, vasculogenesis and lymphagiogenesis
In what ways can tumor vessel markers be used in the clinic?
For direct treatment, drug targeting and tumor imaging
What does this table show?
That although on microscopic level, cancer is identified, they are not at risk for having malignant cancer. This is because the cells are in a dormant stage (=dormancy) and because the cells are not angiogenically active (they don’t have access to nutrients and oxygen so can’t get bigger)
