Chapter 10 Flashcards

1
Q

Is dying of heart break scientifically possible? If so, what is it called and how does it work?

A

> It is referred to as “broken-heart syndrome” (or takotsubo syndrome in Japan)

> it is a stress-induced cardiomyopathy (disease of the heart muscle)

> When an individual endures a significant amount of emotional distress, the body is flooded with hormones that directly impact the heart.

> Rapid and immense levels of these hormones can influence the heart to enlarge and pump blood inefficiently

> these effects are typically transient and most individuals fully recover within two months; however, this intense hormonal cascade can lead to heart failure and in rare cases death

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2
Q

Diseases of the cardiovascular system include those that occur in what organ, what two sytems?

A

> those that occur within the heart and the blood transport or circulatory system (i.e., veins and arteries).

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3
Q

Is CVD a leading cause of death? If so, for which countries?

A

> these diseases are among the leading causes of death for North American men and women

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4
Q

Are people living with chronic CVD? (What do the mortality rates say…)

A

> Fortunately, due to advances in treatment, mortality rates from cardio-vascular disease (CVD) have significantly declined in developed nations such as Canada and the United States

> Since mortality rates have de-clined, and onset of disease has not, this means that many people are living with chronic CVD.

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5
Q

What factors are associated with the onset of CVD and its progression, as well as the quality and quantity of life of those with CVD?

A

> psychological factors
such as depression or behavioural changes that come with the diagnosis?

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6
Q

The optimal management of heart disease requires what?

A

> requires multiple behavioural changes, such as abstinence from tobacco, regular physical activity, and adhering to a heart-healthy diet

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7
Q

Coping with a heart condition and its treatment can also contribute stress in interpersonal relationships and role functioning (e.g., paid and unpaid work), thus impacting what?

A

> impacting quality of life.

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8
Q

The biopsychosocial model provides a framework describing how behavioural and social factors contribute to the onset of CVD- how does it work?

A

> Specifically, injury to the endo-thelium is often caused by hypertension (high blood pressure), diabetes (problems regulating blood sugar), and hyperlipidemia (too much cholesterol).

> These injuries are associated with modifiable behavioural and social risk factors such as smoking, abdominal obesity, physical inactivity, unhealthy diet, and psychosocial distress

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9
Q

A temporary restriction of blood flow is known as what?

A

> ischemia (tissue cells remain alive but their functioning is disrupted), in which the heart tissue by the vessel is deprived of oxygen.

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10
Q

In the instance of complete blockage, there is no distribution of oxygen and other nutrients to the tissues supplied by that artery- what is this called when it occurs in the arteries?

A

> When this occurs in the coronary arteries serving the myocardium (heart muscle), this is known as a “heart attack,” or myocardial infarction (mi).

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11
Q

The continuum from unstable angina (i.e., ischemia causing chest pain that does not remit with rest) to MI is known as what?

A

> as acute coronary syndrome

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12
Q

What is the end stage of heart disease?

A

> Heart failure is an end-stage of heart disease, when the heart cannot pump sufficient blood to meet the demands of the body

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13
Q

What is the average life span of heart disease?

A

> the average lifespan of heart-failure patients is approximately five years following hospital discharge

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14
Q

What are other forms of heart disease?

A

> there are other heart diseases related to the function of the valves (ensures directional flow)

> the contraction of the heart (disturbances called arrhythmias,

> some of which can cause sudden cardiac death

> the heart muscle (i.e., cardiomyopathies),

> infections,

> structural defects (i.e., congenital heart disease).

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15
Q

What are the warning signs of a heart attack?

A

> Chest discomfort- uncomfort-able pressure, squeezing, fullness, or pain.

> Discomfort of other areas of the upper body—one or both arms, the back, neck, jaw, or stomach.

> Shortness of breath—with or without chest discomfort.

> Other signs—may include breaking out in a cold sweat, nausea, or light-headedness.

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16
Q

What are the symptoms of heart attack for men?

A

> “experience classic warning signs”

> Uncomfortable pressure, fullness, squeezing or pain in the centre of the chest that goes away and comes back

> Pain that spreads to the shoulders, neck, or arms

> Chest discomfort with lightheadedness, fainting, sweating, nausea, or shortness of breath

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17
Q

When are the symptoms of heart attack for women?

A

> Shortness of breath or difficulty breathing

> Nausea, vomiting or dizziness

> Back or jaw pain

> Unexplained anxiety, weakness, or fatigue

> Palpitations, cold sweats, or paleness

> may experience the classic symptoms, but they are often milder

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18
Q

What is the trigger for heart attacks in women?

( What type of stress )

A

Emotional Stress

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19
Q

What is the trigger for heart attacks in men?

A

> Men most often report physical exertion prior to heart attacks.

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20
Q

In Canada, how many individuals experience an MI each year? How many of these result in death?

A

> over 70,000
14,211 result in death

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21
Q

How many in the US experience MI and how many will experience angina?

A

> In the United States, recent annual estimates suggest that 750,000 adults will have an MI and 3.4 million will experience angina each year

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22
Q

There is an associated financial burden; CVD costs the Canadian and American economies what?

A

> more than $12.1 billion and $316.6 billion, respectively

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23
Q

What are the disparities in heart disease? (specifically with relation to ethnicity)

A

> CD tends to occur in men and women of African ancestry at an earlier age than in Caucasians

> death rates are higher in persons of African ancestry across all age categories

> ethnic minority groups have been shown to have relatively more limited awareness regarding CVD risk factors and less access to health care

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24
Q

What do the disparities of CVD highlight in terms of treatment?

A

> these discrepancies high-light the need for individualized, culturally sensitive methods of CVD prevention, diagnosis, and treatment

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25
Q

What are the major signs of heart failure?

C,T, SOB, PE, PLE, SINTA, PAGW, SINAAL

A

> coughing
Tiredness
Shortness of breath
Pulmonary edema (excess fluid in lungs)
Pleural effusion (excess fluid around lungs)
Swelling in abdomen (ascites)
Pumping action of the heart grows weaker
Swelling in ankles and legs

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26
Q

What are the disparities by sex and socio-economic status for CVD?

A

> women often receive less aggressive treatment and are more likely to die in the early months after a heart attack

> CVD risk factors are most common among people in lower income brackets

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27
Q

Is heart failure increasing in prevalence? If so, do to what?

A

> Heart failure is increasing in prevalence, in part due to our aging population demographic

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28
Q

Once a patient is diagnosed with acute coronary syndrome, it is important to do what? How is it done?

A

> it is important to acutely restore blood flow to the heart.

> Often, revascularization interventions are performed in hospital to restore sufficient blood flow.

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29
Q

What are the two revascularization interventions?

A

> Revascularization pro-cedures include angioplasty, also known as percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) surgery.

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30
Q

What is PCI? How long does it take to complete?

A

> PCI is a procedure in which a catheter is used to place a mesh tube in the coronary vessels that have nar-rowed.

> This mesh tube (“stent”) is then expanded so blood can again flow through the vessel to the heart muscle

> a day procedure

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31
Q

What is CABG? How long does it take to complete?

A

> CABG uses arteries or veins from another area of the body to circumvent the blocked flow in the coronary arteries restoring the delivery of the blood supply to heart tissues

> CABG requires an approximately week-long hospitalization and extended re-covery period at home.

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32
Q

What is the breakdown of the percentage of costs due to cardiovascular disease in Canada?

A

1) Indirect costs− 65.7%

2) Mortality (as cost of premature death) 41.7%

3) Direct costs − 34.3%

4) Long-term disability 18.7%

5) Hospital care 17.8%

6) Drugs 9.6%

7) Physician care 6.9%

8) Short-term disability 5.3%

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33
Q

With respect to CVD, what is secondary prevention?

A

> Secondary prevention refers to the initiation of treatments to stop or slow the progression of diseases and disabilities once they have already occurred.

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34
Q

Secondary prevention of acute coronary syndrome specifically includes what?

A

> reducing CVD risk factors through behavioural approaches (e.g., exercise, smoking cessation) and pharmacotherapy (e.g., aspirin, cholesterol-lowering drugs).

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35
Q

When the pumping function is permanently damaged, as in heart failure, is there a cure? what about treatment?

A

> no cure.
Heart transplantation is the most enduring treatment approach.
*However, there are insufficient organs available to meet need

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36
Q

Because there are not enough heart organs, what is a new advancing approach?

A

> Mechanical circulatory support = the ventricular assist device

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37
Q

What is a benefical strategy to reduce psychological distress in those with acute coronary syndrome and CVD?

What type of interview?

A

> Motivational interviewing

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38
Q

Following PCI or CABG, what are patients ideally referred to?

A

> ideally referred to CR, which is a compre-hensive secondary prevention program that provides risk-factor modification through education, behavioural counselling and structured exercise train-ing.

> CR programs provide social support to patients with CVD, and may offer stress-management classes and programs targeting psychological distress

> Participation in CR significantly reduces cardiovascular mortality and repeat hospitalization rates, regardless of the setting in which the program is offered

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39
Q

Although they are highly effective, CR programs are underused, what is a reason why?

A

> Barriers to CR are multifactorial and thus efforts to improve access to and participation in CR should target patients, providers, and the broader health-care system

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40
Q

Traditional risk factors (e.g., diabetes, hypertension, smoking, dyslipidemia) only explain how many CVD cases?

A

> only explain about two-thirds of new CVD cases

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41
Q

In the international INTERHEART study, over 24,000 people from 52 countries who had MIs were age-and sex-matched to people who had not. Patients who had MIs were more likely to do what?

A

> were more likely to recall periods of perceived work and home stress, financial stress, and have experienced major life events (i.e., business failure, intra-family conflict), in addition to depression and perceiving lower control over their lives, during the 12 months prior to their car-diac event

> overall they exeprienced perceived job and home stress, social isola-tion, depression, anxiety, and even some personality traits.

42
Q

What were the things that the participants in the INTERHEART study recalled considered?

A

psycholgical risk factors

43
Q

The cardiovascular effects of acute stressors have been demonstrated in stud-ies of people experiencing what?

A

> people experiencing bereavement, environmental disasters, and terrorist attacks.

> For ex-ample, there is heightened risk for cardiovascular events following the death of a spouse for both men and women

> During the first month fol-lowing the 1995 Hanshin-Awaji earthquake in Japan, there was a significant increase in MI and stroke among those living near the epicentre.

> It appeared that the risk of a fatal outcome following this acute stressor was associated with having underlying CVD prior to the earthquake. In another study, individuals residing in Chicago, New York, Mississippi, and Washington D.C. had significantly greater systolic blood pressure two months following the 11 September 2001 terrorist attacks + data col-lected from 16 New Jersey emergency departments revealed a 49 per cent increase in patients who experienced an MI 60 days following the September 11th attacks

44
Q

This rapid onset of impaired cardiac functioning, followed by an identifiable stressor, is known as what?

A

> is known as stress-induced cardiomyopathy or “broken-heart syndrome”

45
Q

It has been suggested that acute mental stress can contribute to what cardiac condition?

A

> can contribute to cardiac ischemia, particularly “silent” ischemia (i.e., no overt chest pain).

46
Q

Rozanski et al. (1988) assessed cardiac functioning in patients with CVD while they completed either exercise or a series of mental tasks that included arithmetic, reading, and public speaking - what mental task was associated with myocardial ischemia

A

> a majority of the patients, mental stress, particularly public speaking, was accompanied by myocardial ischemia similar to what was ob-served during exercise.

47
Q

The core feature of chronic stress is what?

A

> is that the person perceives himself or herself as having limited control over the situation in which the chronic stressor(s) occur.

48
Q

Stressors that have been shown to impact CVD onset and prognosis include what?

A

> job strain, family conflict, and social isolation.

49
Q

What aspect of work is harmful to heart health?

A

> Low decision-making control
and an im-balance between employees’ efforts at work and the rewards they gain in return

50
Q

A Canadian study established that chronic job strain, as characterized by “high psychological demands” and “low decision control,” is a predictor of what?

A

> is a predictor of recurrent CVD events following an initial CVD event

51
Q

What occurred in the Canadian study of chronic job strain? What was found?

A

> survival rates for patients with greater chronic job strain were lower.
* these patients had a higher risk for fatal CVD, MI, or angina in the two to six years after their initial MI

52
Q

As per the effort–reward model, there is an increased risk of CVD and poor physical and mental health functioning in employees who perceive what? What does this model emphasize?

A

> an imbalance between the work they put in for their employer and their rewards
The effect of effort–reward imbalances are particularly evident in employees with limited occupational social support networks

53
Q

Another job strain is shift work that varies from the typical eight-hour workday, disrupts normal biological rhythms- what has it been associated with?

A

> it has been associated with a higher prevalence of atherosclerosis and MI.

54
Q

Shift workers often have more CVD risk factors, such as:

A

> smoking and reduced physical activity.

55
Q

The negative CVD outcomes associated with shift work occur in people at what age? Is this age expected (if not - what evidence amounts to it?)

A

> at a younger age than would be expected in the general population

56
Q

What was found in the Landmark nurses Health study with respect to CVD, MI, and death rates.

A

> female nurses who worked rotating night shifts had a higher rate of MI and death from CVD

> the risk for CVD among women who worked > six years on these shifts was 1.5 times > than it was among the women who were not on these shifts

57
Q

In the Framingham Offspring Study, men and women were assessed on measures of marital status, marital strain, and risk fac-tors for CVD, then followed for 10 years. What was found?

A

> In this study, the development of a CVD event was primarily related to the reaction to conflict with one’s spouse

> Importantly, men and women who had marital conflict tended to have higher blood pressure compared to individuals who engaged in collaborative problem-solving

> The impact of marital strain on CVD prognosis appeared to affect both men and women.

58
Q

Approximately what per cent of Americans over the age of 45 have family caregiving responsibilities?

A

> 12%

59
Q

Providing support to a spouse or other family member who requires assistance increases the risk of CVD onset in the caregiver. Why is this?

A

> his is often due to chronic stress and the specific strains as-sociated with physically and psychologically demanding tasks, financial difficulty, filling multiple roles, social isolation, and watching the deterioration and suffering of another person.

60
Q

What kind of person is a caregiver?

A

> Caregivers are often older persons and their own health and emotional adjustment to the situation may de-cline during the process of taking care of another

61
Q

What is a positive benefit from caregiving?

A

> some recent work suggests that the fulfillment that comes with caregiving can prop up the health of the caregiver

62
Q

What type of social networks have been associated with lower incidences of CVD?

A

> Social networks, such as family, friends, co-workers, pets and even the patient-centred care network have been associ-ated with a lower incidence of CVD

63
Q

What relationships are particularly protective from risk of CVD?

Not the type of relationship but (quanity not …)

A

> Higher-quality relationships

64
Q

With respect to CVD, what has social isolation been related to?

A

> social isolation has been related to de-creased heart functioning and poor health behaviours.

65
Q

How does social isolation affect CVD?

A

> those who know fewer than three people well enough to visit their home are at an increased risk for CVD

> social isolation and loneliness are associated with a greater risk of inactivity, smoking, multiple health-risk behaviours, and hyperten-sion

> People who feel that they have limited social support or who live alone are more likely to die, to have a recurrent cardiovascular event, and to experience decreased quality of life and/or depression

66
Q

Two psychological conditions—have been related to CVD onset and prognosis. What are those two conditions?

A

> depression and anxiety

67
Q

he difference between clinical depression and psychological distress (“the blues”) relates to what?

A

> relates to the severity and duration of the symptoms, and the degree of impact on one’s life roles.

68
Q

Adults with CVD have a higher prevalence of what psychological condition? Is it a risk factor for CVD?

A

> depression
A history of depression is a known psychological risk factor for CVD
* BUT the risk for CVD onset remains elevated (albeit lower) for individuals who present with sub-clinical symptoms of depression

69
Q

There is an association between what two factors in patients who have CVD?

A

> depression and death

> Depression in the first two years after MI predicts poor prognosis in terms of cardiac symptoms, quality of life, disability, and death (moreso evident in women)

> Specifically, depression in CVD patients is related to two times greater mortality in the two years after CVD diagnosis, when compared to non-depressed

70
Q

The documented prevalence of cardiac patients meeting the criteria for at least one anxiety disorder is approximately what percent?

A

> 36%

71
Q

CVD populations have a higher risk of anxiety disorders irrespective of what factors? Is there a gender gap in this difference?

A

> irrespective of socio-economic background, geographic location, and culture

> However, the impact of anxiety on CVD appears to be stronger for men than for women

72
Q

Which disorder (Depression or Anxiety) affects CVD more?

A

> the role of anxiety in the development of CVD is less than that of depression and may be dependent on the specific anxiety-disorder subtype

> i.e., the presence of phobic anxiety increases the risk of sudden cardiac death, but not of non-fatal MI

73
Q

Do anxiety levels persist after a cardiac event? What is anxiety related to with respect of CVD?

A

> anxiety levels tend to be high following a CVD event, and have been
shown to persist for longer than six months

74
Q

Post-MI anxiety has been associated with a range of CVD events, including:

A

> ischemia, recurrent MI, and sudden death

> High levels of anxiety are also related to longer hospital stays (which is costly to the health system, and distressing for patients and their families) and reduced quality of life

75
Q

What kind of impact does anxiety have on CVD?

A

> there is more evidence to suggest a differential impact of anxiety dependent on disorder sub-type

> i.e., people with

76
Q

Which type of anxiety may actually help CVD?

A

> It was suggested that the worrying tendencies among individuals with GAD might actually promote help-seeking behaviour and better CVD self-management

77
Q

Aside from depression and anxiety, what other psychological conditon may affect CVD onset?

A

> Post-traumatic stress disorder (PTSD) has also emerged as a potential contributor to CVD onset.

> It has been linked to poor health behaviours and may be associated with increased risk of atherosclerosis and mortality

> Furthermore, PTSD may occur in response to a traumatic cardiovascular event, thus further increasing CVD recurrence and death

78
Q

What studies show support for how anxiety affects CVD? What do the results suggest?

A

In one study, CVD patients with co-morbid depression and GAD were not at a greater risk for poorer outcomes (cardiac death, cardiac arrest, or revascularization procedures) than those patients who had either major depression or GAD alone

> In another study, anxiety alone (not including depression) was an independent risk factor for hospitalization and outpatient clinic visits

> this suggests that although depression and anxiety are highly co-morbid, they may relate to CVD in different ways

79
Q

What personality types was the first aspect to be hypothesized to have an independent role in the onset of heart disease.

A

> Type A personality was the first aspect of personality hypothesized to have an independent role in the onset of heart disease

80
Q

What other personality type has been linked to CVD?

A

> the focus of personality subtypes has also centered on the Type D personality, referring to people who display both a high level of negative affect and social inhibition

> linked to severity - but the results are weak.

81
Q

Notably, there are significant associations between health-related outcomes and positive psychological constructs such as what for those with CVD?

A

> such as vitality, optimism, hope, positive affect, and happiness

82
Q

DuBois and colleagues (2015) explored this relationship (positive psychology( among cardiac patients and found a significant correlation between what factors?

A

> found a significant correlation between positive psychological states/ well-being and a reduced risk of mortality and rehospitalization.

83
Q

When people who have survived a CVD trauma such as an MI begin to recognize benefits and take steps towards positive changes in their lives, they may undergo what process of change?

A

> they may undergo “post-traumatic growth,” defined as the experience of positive consequences arising from the struggle with a traumatic ex-perience.

> The resulting transformation is thought to lead not only to a return to previous levels of well-being, but to a higher level of functioning in some aspects of life

84
Q

Psychological risk factors/disorders are commonly assessed via self-administered psychometric-ally validated questionnaires or surveys. For those whose responses suggest a potential mental health problem, what occurs?

A

> clinical interviews by a trained professional (e.g., psychiatrist or psychologist) are required to “diagnose” a psychological disorder.

85
Q

Notably, most medical care for cardiac patients focuses on their physical health, despite the large burden of psychological distress in those with heart disease. Some experts recommend as a result?

A

> Some experts recommend screening for psychological distress (i.e., brief surveys of depression) within the context of rou-tine cardiac care for patients

> Unfortunately, however, psychological disorders are under-recognized and undertreated in people with CVD

86
Q

What is the gold standard for diagnosis of a cardiac patient with a mood or anxiety disorder?

A

> Diagnosis of a cardiac patient with a mood or anxiety disorder can be complicated by the fact that many symptoms of depression or anxiety, are similar to that of CVD

> For these reasons, structured diagnostic interviews are considered the gold standard

87
Q

What scales are used to diagnose mood/anxiety disorders in CVD patients?

A

> Patient Health Questionnaire (PHQ) (Kroenke, Spitzer, & Williams, 2003) and the Hospital Anxiety Depression Scale (HADS)

88
Q

Many scales are available to assess social support, but these are typically administered within the research setting- which ones are used?

A

> One recommended measure in the CVD literature is the ENRICHD (Enhancing Recovery in Coronary Heart Disease) Social Support Inventory (ESSI)

89
Q

In the laboratory setting, hostility, arguably the most hazardous trait of the Type A personality, can be measured via what scale?

A

> can be measured via the Cook-Medley Hostility (Ho) Scale

90
Q

What traits (measured via the HO scale) are most predictive of mortality?

A

> High scores on cynicism, hostile affect, and aggressive responding

91
Q

What class of anit-depressants are used for CVD patients with depression? Which aren’t?

A

> selective serotonergic reuptake inhibitors (SSRIs) is recommended = given their efficacy and safety in this population

> some antidepressants such as monoamine oxi-dase inhibitors and tricyclic antidepressants have cardiotoxic effects and are rarely prescribed to patients with cardiac disease

92
Q

An initial study to evaluate antidepressant medication in CVD patients was what study?

A

> was the Sertraline Antidepressant and Heart Attack Randomized Trial
(SADHART)

93
Q

What were the results of the SADHART study?

A

> In this study, sertraline was not associated with negative changes in any cardio-vascular indicators, suggesting that it is safe for use in CVD populations

> sertraline was more effective than a placebo in reducing depressive symptoms.

94
Q

More recently, Glassman, Bigger, and Gaffney (2009) conducted a seven-year follow-up study of the SADHART participants. They found what?

A

> they found that baseline depression severity and a lack of improvement of depressive symptoms, regardless of being in the sertraline or placebo group, were the two strongest predictors of mortality.

> These results highlight the importance of long-term follow-up of depressed cardiac patients to ensure treatment is sufficient to achieve remission and that patients do not relapse.

95
Q

What was found in the MIND-IT study? Was it similar to SADHART?

A

> Mir-tazapine is part of a newer class of antidepressants, activating serotonin and other receptors in the brain involved in mood.

> In MIND-IT, MI patients who received mirtazapine had lower depressive symptoms at follow-up.

> Similar to SADHART, those who responded best to the antidepressant treatment tended to be those with a history of depressive episodes.

96
Q

What is the difference of CBT and IPT (interpersonal psychotherapy)

A

> As indicated in previous chapters, the goal of CBT is to identify cognitive patterns and behaviours that generate these psychological manifestations, while IPT is focused more on the patient’s relationships and social environment.

97
Q

What was the ENRICHD trial designed to do?

A

> the ENRICHD trial was designed to address whether treating depression and increasing social support would reduce recurrent CVD events and death

98
Q

What were the results of the ENRICHD trial?

A

> Results were disappointing;

> Treatment allocation had no effect on recurrent MI or death
during the four-year follow-up period.

> Depression symptoms were reduced and social support was significantly increased in the intervention group vs patients in usual care; however, benefits were not sustained over the long term

> findings showed that improvements in mood and social support were found to be related to the adherence of the patient to the CBT-related homework assignments as well as exercise instead

99
Q

What was the CREATE trial? What did it test?

A

> Another trial tested combination therapy: an SSRI antidepressant, citalopram, alongside IPT.

> The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) study Cognitive behavioural therapy is used to identify maladaptive thoughts and behaviours that contribute to anxiety and mood dis-orders.

> Results showed that citalopram was significantly better than the placebo in the reduction of depression scores 12 weeks after initiation of the antidepressant treatment. There was no effect of IPT.

> Therefore, the investigators recommended that citalopram be considered as a first-line treatment for co-morbid depression in CVD patients

100
Q

Is stress management training (SMT) an effective psychological intervention? (What study points to yes?)

A

> In one randomized trial, patients who received either comprehensive CR, or comprehensive CR plus stress management training (SMT), had significant improvements in cardiac biomarkers, physical activ-ity, and perceived level of stress.

101
Q

In the Secondary Prevention in Uppsala Primary Health Care Project (SUPRIM) trial, what occured?

A

> CVD patients who were randomized into the CBT/stress management intervention demonstrated a significant decrease in recurrent cardiovascular events compared to controls.

> Moreover, higher attendance rates across the 20 CBT stress management sessions was associated with the lowest recurrent CVD risk

102
Q

At what point of intervention for CVD is physical activity involved in?

A

> Physical activity, a core component of CR, is effective in the primary and secondary preven-tion of CVD