Chapter 1: The Logic of Disease: Pathways and Networks

Question 2

Glucose-6-phosphate is an important hub in the cellular biochemical network for carbohydrate metabolism, because it can be converted to many compounds by a single enzymatic reaction. Which one of the following compounds, however, is not within a single enzymatic reaction step from glucose-6-phosphate?
A. fructose-6-phosphate
B. glucose
C. glucose-1-pohsophate
D. 6-phosphogluconolactone
E. UDP-glucose

Answer 2

E. UDP-glucose

Question 3

Random mutagenesis of a mammalian genome generally reveal the following observation: cellular physiology can be robustely sustained initially after a large number of mutation events, but the mutation of one additional gene would lead to the collapse of cell physiology. Knowing the properties of biological netowrks, which one of the following statement is most likely to be true?
A. cell physiology maintenance requires a network in which few nodes have very high connectivity and many more nodes with low connectivity (i.e. hub like configuration)
B. cell physiology maintenance rquires a network with random connectivity
C. cell physiology maintenance requires a very precise number of normal gene (i.e. it demonstrates a threshold effect)
D. cell physiolgy maintaenance requires all of hte genes within the genome
E. cell physiology maintenance requires an unpredictable number of genes

Answer 3

A. cell physiology maintenance requires a network in which few nodes have very high connectivity and many more nodes with low connectivity (i.e. hub like configuration)