Chapter 1 & 4 Understanding Flashcards
Rate of exchange of materials depends on what?
SURFACE AREA
Rate at which materials are being used / produced depends on what?
VOLUME
What is 1 advantage of being multicellular?
division of labour (differentiation)
How can SA:V ratio be maximised?
cell division
compartmentalisation
folding up
thin
narrow
spherical
Outline features of stem cells
- capacity to DIVIDE & DIFFERENTIATE along dif pathways
- self-renewal + potency
totipotent example
zygote
pluripotent
can differentiate into any cell found in embryo
- anything except extra-embryonic cells like placenta
multipotency
adult stem cells that can differentiate into closely related cell types
e.g. bone marrow –> dif blood cells
unipotency
adult stem cells that can dif. into their own lineage
- e.g. heart muscle cells, neuron
most cells are unipotent
Functions of life
metabolism
response
homeostasis
growth
excretion
reproduction
nutrition
What are advantages of compartmentalisation?
- enzymes / substrates concentrated in small area –> better metabolism
- pH & other conditions at optimum levels
- damaging substances isolated
Outline functions of membrane proteins
- hormone binding site
- immobilized enzyme (Catalyst)
- cell adhesion
- cell-to-cell communication (glycoprotein)
- channels for passive transport
- pumps for active transport
What is the function of cholesterol?
- controlling fluidity
- reducing permeability to hydrophilic substances
- prevents crystallisation
- helps membranes curve into concave shape
- formation of vesicles
Outline the process of exocytosis
- proteins synthesised by ribosomes –> enter rER
- vesicles bud off from rER
- carry proteins to Golgi apparatus
- Golgi apparatus MODIFIES proteins
- vesicles bud off from Golgi apparatus & carry modified proteins to plasma membrane
Outline the activity of cyclins
- groups of proteins that regulate timing of cell cycle –> progression to next stage
- cyclins bind to enzymes (cyclin-dependent kinases)
- kinases become active & attach phosphate groups to other proteins in cell
- phosphate triggers other proteins to become active & carry out tasks for that stage
- cyclins must reach threshold concentration to allow progression to next stage
- ensures cells only divide when needed
Distinguish b/w cytokineses in plants & animals
PLANTS:
- cell plate forms at equator
- new cell walls produced
ANIMALS:
- cleavage furrow forms
- separates daughter cells
- actin + myosin proteins form contractile ring under plasma membrane
- ring is formed at equator of cell
- plasma membrane pulled in
Universality of genetic code
64 codons of genetic code = same meaning in cells of organisms w/ small variations
Origin of 1st cells
- production of carbon compounds (e.g. sugars/amino acids)
- assembly of organic compounds into polymers
- formation of polymers that can self-replicate
- formation of membranes to package the organic material
Function of pilli
- shorter, thinner than flagella
- found in prokaryotes
- assist w/ movement
- conjugation (exchange of genetic material)
- adherence to surfaces
What is cell wall made of in plants?
polysaccharide cellulose
What is cell wall made of in most bacterial cells?
peptidoglycan
What is the flagella made of?
long microtubules
What is the role of centrioles?
- organise microtubules
- help determine location of nucleus + other organelles
- NOT FOUND IN FLOWERING PLANTS / FUNGI
What is the function of microtubules?
- support + movement
found in ALL EUKARYOTIC CELLS
Functions of life in paramecium
- nutrition –> endocytosis
- growth –> obtains nutrients from organic matter
- response –> beating of cilia
- excretion –> expels waste products of metabolism
- homeostasis –> expels water using contractile vacuoles
- reproduction –> reproduces asexually or sexually
- metabolism –> enzymes catalyse reactions
Functions of life in chlorella
- nutrition –> photosynthesis
- growth –> increase in size due to photosynthesis / absorption of minerals
- response –> chlorophyll pigments absorb light
- excretion –> oxygen diffuses out of cell
- homeostasis –> expels water using contractile vacuoles
- reproduction –> asexually or sexually
- metabolism –> enzymes catalyse reactions
Functions of life in chlorella
- nutrition –> photosynthesis
- growth –> increase in size due to photosynthesis / absorption of minerals
- response –> chlorophyll pigments absorb light
- excretion –> oxygen diffuses out of cell
- homeostasis –> expels water using contractile vacuoles
- reproduction –> asexually or sexually
- metabolism –> enzymes catalyse reactions
Magnification = ?
SIZE OF IMAGE / REAL-LIFE SIZE
Potassium channel in axons (facilitated diffusion)
- Open in response to depolarisation of axon membrane (+ inside)
- Allow K+ to exit via facilitated diffusion causes repolarisation
- Globular subunit closes the channel (“ball & chain”)
- Channel returns to original shape
Sodium-Potassium Pump (Active Transport)
- 3 Na+ ions from INSIDE of axon bind to pump
- ATP attaches to pump & transfers phosphate to pump
- Pump changes shape + opens to outside of axon
- 3 Na+ released, 2 K+ enter
- The attached phosphate is released, pump changes shape again
- K+ ions released inside, resting potential electrochemical gradient
Stargardt’s macular dystophy
- EYE
- Genetic disease in 6-12 year olds
- Recessive mutation of ABCA4 gene
- Membrane protein used in active transport in retinal cells malfunctions
- Photoreceptive cells degenerate
- Embryonic stem cells injected into eyes
- Cells attach to retina, differentiate into healthy retinal cells
Leukemia
- cancer in bone marrow
- mutations in genes resulting from over-production of white blood cells (leukocytes)
- Large needle inserted into bone
- Stem cells extracted + stored by freezing
- Adult stem cells only have potential for producing blood cells
- Chemotherapy kills all cancer cells in bone marrow
- Bone marrow loses ability to produce blood cells
- Stem cells (HSCs) returned to patient
- Produce healthy blood cells
Define oncogenesis
the formation of tumours
- starts w/ mutations in genes involved in controlling cell cycle
- chemicals (mutagens) cause mutations –> tumours
- metastasis: spreading of tumours from primary to secondary (from benign to malignant)
Why is mitosis needed?
- embryonic development
- growth
- tissue repair
- asexual reproduction
Outline events that occur in interphase.
- increase in mass + size
- carries out many cellular processes
- synthesises proteins
- replicates its DNA for mitosis
- increases # of mitochondria &/or chloroplasts