Chapter 1-4 Flashcards

1
Q

A substance used to treat, prevent, or diagnose a Dz in animals

A

Drug

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2
Q

Study of drugs

A

Pharmacology

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3
Q

Motion through the body and tissues, whether absorbed or excreted. Indicated the study of absorption, distribution, biotransformation, and excretion of drugs.

A

Pharmacokinetics

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4
Q

How the body is affected by the drugs

A

Pharmacodynamics

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5
Q

treatment of Dz with medicine

A

Pharmacotherapy

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6
Q

Field of medicine that studies drug used in treatment of Dz

A

Pharmacotherapeutics

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7
Q

FDA

A

Food and Drug Administration

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8
Q

Ensues approval of Veterinary medicines

A

FDA

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9
Q

Therapeutic agents derived from living organisms, such as vaccines, antibodies, and toxiods.

A

Biologics

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10
Q

Governed by the USDA

A

Biologics

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11
Q

AMDUCA

A

American Medical Drug Use Clarification Act

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12
Q

Allows Vets to Px extra label use of a drug, used for animals for specific circumstances

A

AMDUCA

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13
Q

ADUFA

A

Animal Drug User Fee Act

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14
Q

Collect subsities of certain animal drug reviews

A

ADUFA

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15
Q

AGDUFA

A

Animal Generic Drug User Fee Act

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16
Q

Study of ways to improve the timeliness and predictability of animal generic drug review process

A

AGDUFA

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17
Q

OTC

A

Drugs purchased ‘Over The Counter’

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18
Q

Drug limited under the supervision of a Vet or Physician

A

Prescription Drug

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19
Q

Relationship between Vet/client for which vet assumes responsibility for making clinical judgments regarding the health of the animal/patient and the need for medical Tx and the client agrees to follow Vet’s instructions

A

Vet/Client/Patient Relationship

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20
Q

Drug used in a manner not specifically described on the FDA approved label

A

Extra-label

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21
Q

Food Animal Residue Avoidance Databank

A

FARAD

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22
Q

considered dangerous b/c of their potential for human abuse or misuse

A

Controlled Substance

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23
Q

DEA

A

Drug Enforcement Act

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24
Q

Enforces control of controlled substances through the Comprehensive Drug Abuse Prevention and Control Act of 1970 (Controlled Substance Act)

A

DEA

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25
EPA
Environmental Protection Agency
26
Development and approval of Topical Pesticides
EPA
27
Studies preformed to see if drug produces the intended effects and whether it has toxic properties
Preliminary Studies
28
Preformed on lab animals to determine safety and effectiveness of the drug
Preclinical Studies
29
Ability to produce cancer
Carcinogenicity
30
Capacity to cause birth defects
Tetratogenicity
31
INAD
Investigational New Animal Drug
32
EUP
Experimental Use Permit
33
Used for Pesticides
EUP
34
APHIS
Animal and Plant health inspection services
35
Used for Biological
APHIS
36
Conducted on Target Species and are done to evaluate the drug's safety and effectiveness in that species
Clinical Trials
37
Shows how long drug remains stable and effective for use
Shelf-life
38
NADA
New Animal Drug Application
39
Occurs hours following a test dose
Short Term Tests
40
Typically run for 3 months to 24 months of repeated dosing, to check animal's organ system for toxicity damage
Long Term Tests
41
Tests done to determine reproductive effects, both short and long term
Special Tests
42
To determine the dose at which the drug does organ or tissue damage, whether injury or death
toxicity evaluation
43
Intensity of effect measured on a subjective scale (1-3 or 1-10)
Parameters
44
Produces adverse reactions may prompt the manufacturer to terminate drug testing
Short term Toxicity test
45
Dose of drug that causes desired effect
Effective Dose
46
Dose of drug that is toxic or lethal to 50% of tested individuals
Lethal Dose
47
Important test to determine Toxicity phase
Margin of Safety
48
The drug dosage or dose that produces desired effect with minimal or no sign of toxicity
Margin of Safety/Therapeutic Index
49
A test of drug's effect on a particular physiological system; evaluates toxicity as they effect specific body systems
Systems Oriented Screen
50
Run any where from 3 months to 2 years, to prevent disastrous consequences of drug therapy
Long term toxicity/Chronic Studies
51
Range of a drug is the drug concentration in the body that produces desired effect in the animals with minimal or no sign of toxicity
Therapeutic Range
52
Small sterile prefilled glass containers containing medication for injection
Ampules
53
Mixture of 2 immiscible liquids one being dispersed throughout the other in small droplets
Emulsion
54
Incapable of mixing liquids
Immiscible
55
Concentrated mass of pharmaceutical prepartaion
Bolus
56
An injectable in a substance that delays absorption
Repository/Depot Preparation
57
Administered to the animal by breathing in the drug to Respiratory Tract
Inhalation
58
turned into a gas
volatilized
59
turned into a fine spray
nebulied
60
medicine that goes on the surface of skin or mucous membranes
topical
61
CIDR
Controlled Internal Drug Release
62
PRID
Progesterone releasing intravaginal devices
63
Drug preps dissolved into liquids that do not settle
Solutions
64
undissolved substance dispersed in water; settles
Suspension
65
Amount of a drug administered @ one time to achieve desired effect
Dose
66
Initial dose of drug given to get the drug concentration in the therapeutic range in a very short period of time
Loading Dose
67
Dose of a drug to keep or maintain the drug therapeutic range
Maintenance Dose
68
Total amount of drug given in 24 hr
Total daily dose
69
Amount of drug given per animal species' body weight or measure
Dosage
70
How frequently the dosage is given
Dosage interval
71
Dosage interval + Dosage + Administration Route + Duration of treatment
Dosage Regimen
72
Charged, hydrophilic, do not pass through lipid rich cell membranes, mostly injectables
Ionized
73
No charge, lipophilic, able to dissolve in phospholipid or fat containing cell membrane
Nonionized
74
Molecules are physically taken in or engulfed by cell
Pino/Phagocytosis
75
Movement of drug into the blood stream
Absorption
76
Degree to which a drug is absorbed and reaches the circulation is an important component of absorption
Bioavailability
77
Occurs when molecule changes from ionized to nonionized form as it moves from one body compartment to another
Ion Trapping
78
Physiological movement of drugs from systemic circulation to tissue
Distribution
79
How well the drug is distributed throughout the body based on the concentration of drug in blood
Volume of Distribution
80
Metabolism
Biotransformation
81
Alters metabolism, enzyme system and hence are known as microsomal enzyme inducers
Induce
82
Decreased response to a drug resulting from repetitive use
Tolerance
83
Excretion
Elimination
84
Amount of drug that can be detected in tissues at specific times after administration of drug ceases
Drug Residue
85
with holding period to keep an animal from being sent to market until residue is almost gone and at an acceptable amount
Withdrawal Time
86
time required for amount of drug in body to reduce by half
Half life
87
point at which drug accumulation and elimination are balanced
Steady State
88
3D proteins or glycoproteins that are usually located on cell membrane
Receptors
89
Strength of binding between drug and receptor
Affinity
90
Drug binds to cell receptor and causes action
Agonist
91
Drug inhibits or blocks response of a cell when the drug is bound to the receptor
Antagonist