Chapter 1 Flashcards
1
Q
prostaglandins act through [endocrine, paracrine, or autocrine?] mechanisms
A
paracrine
2
Q
endocrine vs paracrine signaling
A
endocrine involves transport of hormones through the bloodstream, paracrine involves diffusion to nearby cells
3
Q
in ______ signaling, cells both produce and respond to the same hormone.
A
autocrine
4
Q
what are the second messengers in the Gs and Gq GPCR pathways? contrast these pathways.
A
in Gs, the alpha subunit activates adenylyl cyclase, which creates the second messenger cAMP,, which then activates PKA, causing the cellular response.
in Gq, the alpha subunit activates PLC, which splits PIP2 into the second messengers DAG and IP3. DAG then activates PKC and IP3 causes intracellular calcium release.
