Chapers 1, 2, & 3 Flashcards
The study of drugs
Pharmacology
Treatment of DZ with medicines
Pharmacotherapy
Field of medicine that studies drug use in the treatment of disease
Pharmacotherapeutics
The “motion” of drugs
Pharmacokinetics
The study of mechanisms of action of a drug and involves understanding the interactions between the chemical components of living systems and the drugs that enter those systems
Pharmacodynamics
Covers biologics such as vaccines, antitoxins, etc
USDA
Covers pesticides
EPA
Approves drugs and advises medical professionals of its side effects. It also regulates prescription drugs and studies controlled substances and determines their abuse potential
FDA
Started a system of regulating drug dosing
Drugs must be adequately tested to demonstrate it’s safety when used as the label directs
Food, Drug, and Cosmetic Act of 1938
Created to denote a prescription for drugs
Durham-Humphrey Amendment of 1951
Organized all animal regulations to one section of the Food, Drug, and Cosmetic Act
Animal Drug Amendments of 1968
Allowed vets to prescribe as extra-label use for animals under specific circumstances
Animal Medicinal Drug Use Clarification Act (AMDUCA)
Intended to provide drugs for those less common species and indications
Minor Use and Minor Species Health Act of 2001
What does FDA-CVM stand for?
The FDA’s Center for Veterinary Medicine
Ensures that the approved veterinary medicines will not harm animals or at least the harm a drug produces will be outweighed by its benefits
FDA-CVM
Little potential for toxicity when taken as directed
Don’t require special administration
May mask underlying conditions and make diagnosing difficult
Can create drug interactions
OTC products
Potentially dangerous because of toxicity concerns
Administration can be difficult
Vet/Client/Pt relatioship must exist
Caution: The Federal law restricts the use of this drug to use by or on the order of a licensed veterinarian
Prescription drugs
The use of a drug in a manner not specifically described on the FDA-approved label
Extra-Label
FDA’s Role In New Drug Development
5 steps
- Companies submit an INAD application to the FDA
- Company supplies scientific support for the INAD
- Clinical trials are performed
- Drug manufacturers apply for a NADA
- New drugs are then approved or dismissed
The specific amount of a drug that produces a desired effect
Dose
Dose that produces the desired effect in 50% of the population that take it
Effective Dose
Dose that kills 50% of population that take it
Lethal Dose
The 6 Pt Rights
- Right drug
- Right dose
- Right time
- Right route
- Right Pt
- Right documentations
The dose that produces a desired effect
Therapeutic Range
When the drug starts working (enters the plasma)
Onset of Action
Length of time a drug produces a desired effect
Duration of Action
Factors involved in staying within the drug’s therapeutic range
- Route
- Absorption
- Distribution
- Metabolism
- Elimination
Given by a route other than GI
Parenteral
Orally given
Non-parenteral
2 Syringe tips
Slip-Tip
Slip-Lok
Hub is off to the side
Eccentric tip