Chap 4: Neural Conduction & Synaptic Transmission Flashcards
Microelectrodes
Their tips are less than 1000th of a millimeter in a diameter much too small to be see by the naked eye
Membrane potential
The difference in electrical charge between the inside and the outside of a cell
Resting membrane potential
When both electrode tips are in the extracellular fluid, the voltage difference between them is zero
Resting potential
In its resting state with the -70 mV charge built up across its membrane a neuron is said to be polarized
Ionic basis of the resting potential
Like all salts in solution the salts in neural tissue separate into positively and negatively charged particles called ions
Concentration gradients
That is, they are more likely to move from areas of high concentration to areas of low concentration than vice versa
Electrostatic pressure
Any accumulation of charges, positive or negative in one area tends to be dispersed by the repulsion among the like charges in the vicinity and the attraction of opposite charges concentrated elsewhere
Neurotransmitter
Which diffuse across the synaptic clefts and interact with specialized receptor molecules on the receptive membranes of the next neurons in the circuit
Depolarize
The receptive membrane (decrease the resting membrane potential, from -70 to -66 mV
Hyperpolarize
Increase the resting membrane potential from -70 to -72 mV
Excitatory post synaptic potentials (EPSPs)
Known as post synaptic depolarization, they increase the likelihood that the neuron will fire
Inhibitory postsynaptic potentials (IPSPs)
Known as postsynaptic hyperpolarization, they decrease the likelihood that the neuron will fire
Graded responses
The amplitudes of EPSPs & IPSPs are proportional to the intensity of the signals that elicit them
Axon hillock
The conical structure at the junction between the cell body and the axon, but they are actually generated in the adjacent section of the axon
Threshold excitation
If the sum of the depolarizations and hyperpolarizations reaching the section of the axon adjacent to the axon hillock at any time is sufficient to the dispel arise the membrane
Action potential (AP)
Is massive but momentary lasting for 1 millisecond reversal of the membrane the potential from about -70 to +50 mV
Integration
Adding or combing a number of individual signals into one overall signal
Temporal summation
Shows how post synaptic potentials produced in rapid succession at the same synapse sum to form a greater signal
Voltage activated ion channels
Ion channels that open or close in response to changes in the level of the membrane potential
Refractory periods
Th
Refractory periods
There is a brief period of about 1 to 2 milliseconds after the initiation of an action potential during which it is impossible to elicit a second one
Relative refractory period
The period during which it is possible to fire the neuron again, but only by applying higher than normal levels of stimulation
Antidromic conduction
When electrical stimulation of sufficient intensity is applied to the terminal end of an axon, an action potential will be generated and will travel along the axon back to the cell body