Ch.23: Beta Blockers (Swift)

Question 1

where are B1 receptors found?

Answer 1

cardiac m.

Question 2

where are B2 receptors found

Answer 2

bronchial and vascular smooth m. Some in myocardium

Question 3

stimulation of B receptors leads to:

Answer 3

increase in contractility, SA node discharge rate and AV node conduction

Question 4

stim. of B2 receptors leads to:

Answer 4

• increase SA node discharge rate, AV node conduction

- bronchodilation

Question 5

effects of beta blockade

Answer 5

• decrease SA node firing rate –> decr. HR, improved myocardial perfusion
• slowed AV node conduction
• dec. myocardial contractility –> less myocardial O2 consumption

Question 6

uses of beta blockers**

Answer 6

• anti-arhythmic (esp. for SVTs and VTs)
• hypertrophic cardiomyopathy
• CHF when active heart failure is resolved**

Question 7

side effects of beta blockers

Answer 7

• bronchospasm
• bradycardia, AV block, neg. ionotropic effect
• depression, lethargy, insomnia

Question 8

is propanolol selective?

Answer 8

No. Therefore, creates greater decrease in HR than other B-blocers

Question 9

is atenolol selective?

Answer 9

yes, for B1

Question 10

propanolol lipid or water soluble?

Answer 10

lipid

Question 11

atenolol lipid or water soluble?

Answer 11

water

Question 12

rank duration of action of propanolol, esmolol, and atenolol*

Answer 12

atenolol > propanolol > esmolol

Question 13

main use of esmolol

Answer 13

acute anti-arrhythmic agent for SVTs

Question 14

is sotalol selective?

Answer 14

no

Question 15

how does sotalol work?

Answer 15

blocks K channels