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T4- Micro > Ch2 : highlighted notes > Flashcards

Ch2 : highlighted notes Flashcards

S: 5

1
Q

complements are syn in the ___

A

liver

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2
Q

compliments are used during ___ immunity

A

specific

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3
Q

___ enzyme activates the cascade of C2-C9 (classical pathway)

A

C1 esterase

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4
Q

___ enzyme regulates the classical pathway of specific immunity

A

C1 esterase inhibitor

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5
Q

complements for toxin neutralization

A

C1-4

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6
Q

Compliment for opsonization

A

C3b

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7
Q

complement for anaphylaxis

A

C3a,C4a, C5a

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8
Q

complement for neutrophil chemotaxis

A

C5a

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9
Q

complement for cell lysis when membrane is attacked

A

C5b, C6-9

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10
Q

cc: ____ deficiency causes angioedema

A

C1 esterase inhibitor

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11
Q

cc: ____: deficiency leads to sepsis

A

C3

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12
Q

cc: ____: deficiency lead to susceptibility to infection of STDs

A

C5b to C8

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13
Q

MCH antigens are genetically determined by ___

A

chromosome 6

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14
Q

Which regions (3) on chromosome 6 determines class 1 specific antigens

A

Region A,B, C

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15
Q

Which region on chromosome 6 determines class II specific antigens

A

region D

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16
Q

Class 1 MHC are located on the surface of all :_____

A

nucleated somatic cells

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17
Q

Class II MHC is located on surface of ____ cells

A

antigen presenting cells (APC)

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18
Q

cc: HLA-B27 = ______

Class ___ MHC

A 
ankylosing spondylitis 
(class I MHC)
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19
Q 
cc: HLA-DR3= \_\_\_ 
class \_\_\_ MHC
A

SLE

Class II MHC

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20
Q

cc: HLA-BR4= ____

Class ___ MHC

A

RA

Class II MHC

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21
Q

Name the 3 types of hypersensitivity that are mediated by Ig

A

type 1
type 2
type 3

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22
Q

Immediate (anaphylactic) rxn is type ___ hypersensitivity

Name Ig involved

A

type 1 : IgE

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23
Q

cytotoxic rxn is type ___ hypersensitivity

Name Ig involved

A

Type II: IgG or IgM

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24
Q

Immune complex sx is type ___ hypersensitivity

Name Ig involved

A

Type III: IgG or IgM

25
Q

What type of hypersensitivity is mediated by T-cells

A

Type IV

26
Q

delayed or cell-mediated is type ___ hypersensitivity

Name cell involved

A

type IV: T-cells and macrophages

27
Q

Type __ mechanism:
1st exposure–> produces IgE–> binds to mast cells

2nd exposure–> cross links of fixed IgE–> leads to degranulation and release of histamine/ serotonin–> edema

A

Type I anaphylaxis or allergy

28
Q

type ___ mechanism:
antigen attached cell membrane –> IgG r IgM attaches to antigen ny Fab region –> complement gets fixed to Fc region = cell lysis

A

Type II hypersensitivity

29
Q

an antigen will attach to what portion of a Ig

A

Fab

30
Q

a complement or receptor site attached to what portion of an Ig

A

Fc

31
Q

type ___ mechanism:

Ag reacts with Ab–> immune complexes activate C5a–> attracts neutrophils –> release lysosome –> tiss damage

A

Type III

32
Q

cc: serum sickness is a type __- hyersensivity

A

Type III

33
Q

cc: Auto-immune dx’s are type ___ hypersensivity

A

type III

34
Q

cc: TB test is a type ___ hypersensntivity

A

type IV

35
Q

Type ___ mechanism:
T-cells recognize the specific antigen → activate CD4& macrophages → release cytokines → activates CD8 → cause tiss damage

A

type IV

36
Q

____: new antigen that develops at the cell surface of a new tumor

A

Tumor Associated antigens (TAA)
cc: carcinoembryonic antigen (CAE)
alpha fetoprotein (AFP)

37
Q

AI occur due to the breakdown of the mech. that maintains ____

A

auto-tolerance

38
Q

a decr. in CD__ cells can cause a AI

A

CD8 (suppressors and cytolytic )

39
Q

cc______: Ab IgM formed against IgG as antigen

A

RA

type III

40
Q

cc ______: Ab against M-protein of streptococci cross-react with heart M sarcolemma

A

Rheumatic fever

41
Q

cc ____: Autoantibodies against anything with nuclear (DNA)

A

SLE

Cause: vasculitis, arthritis, and acute glomerulonephritis

42
Q

cc____: predisposition to bact. infection (M) w/ HLA-B27

A

Reiter’s sx

43
Q

cc_____: Antibodies against Ach receptors of neuromuscular jxn = M weakness

A

myasthenia gravis

44
Q

cc_____: Autoantibodies to RBC surface = cell lysis

A

hemolytic anemia

45
Q

cc__:Autoantibodies to the gastric parietal cells (intrinsic factor) → vit B12 deficiency

A

pernicious anemia

46
Q

cc_____: Autoantibodies to TSH receptors on the surface of follicular cells

A

hyperthyroidism

47
Q

cc___: Autoantibodies to thyroglobulin

A

thyroiditis (hashimoto’s)

48
Q

cc: _____: Defect on 3rd and 4th pharyngeal pouches→ defect development of thymus and parathyroid glands → less mature T cells and hypocalcemia

A

thymic aplasia (diGeorge’s sx)

49
Q

cc_____: T cell deficiency to candida albicans (fungi) → infection

A

Chronic mucocutaneous candidiasis

50
Q

cc____: x-linked recessive (boys) → low levels of all Ig→ pyogenic bact. Infection 6-9 mo. After birth

A

Bruton’s agammaglobulinemia

51
Q

cc___: resurrent sinus, respiratory and intestinal infections

A

selective Ig Deficiency

52
Q

cc____: : defect in bone marrow → failure of T & B cells to become immunocompetent = recurrent infection

A

combo T & B cell dificienies

53
Q

cc______ T and B deficient dx has a triad of:

  1. recurrent pyogenic bact. Infection
  2. bleeding
  3. eczema
A

Wiskott- aldrick sx

54
Q

cc___: Ataxia and telangiectasia

A

ataxia - telanglectasia

55
Q

CC____: Failure of neutrophil lysosomes to empty their contents into the organism → recurrent pyogenic infection

A

Chediak-Higashi sx

56
Q

cc___: Lack of NADPH oxidase enzyme req. to produce H2O2 to kill org’s→ recurrent pyogenic infection

A

Chronic granulomatous dx (CGD)

57
Q

cc_____: Reduced helper (CD4) T-lymphocytes→ bc of a virus

A

AIDS

58
Q

most common cause of death in AIDS

A

pneumocystic jiroveci carinii

T4- Micro (11 decks)

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