Ch.19 Flashcards
Pancreas divisum
Failure of the ventral and dorsal fetal duct systems to fuse
Papilla of vater doesnt do main drainage tehn
Annular pancreas
band like ring on normal pancreatis ittus that encircles teh second portion of duodenum
Mutation PDX1
Pancreatic agenesis
SPINK1
Acute pancreatitis
AR
Loss of fxn: preventing inhibition of trypsin
PRSS1
Acute pancreatisi
GOF: mutation trysinogen making trypsin resistant to self inactivation
AD
Increased plasma amylase
Acute pancreatitis
Chronic pancreatitsi
- due to
- mediators produced
Alcohol abuse
TGF beta, PDGF
Presence of IgG4 secreting plasma cells in pancreas
-tx
Autoimmune pancreatitis
-steroids
Unilocular
Thin walled
Cuboidal epithelial lining
Thin fibrous capsule
Congenital cysts
Inside or outside pancreas
Localized collections of necrotic and hemorrhagic material
Lack epitehlial lining
Tx:
Pseduocysts
spontaneously resolve
Multicystic Tail of pancreas Small Lined by glycogen rich cuboidal cells Clear, thin straw colored fluid
Serous cystic neoplasms
Tail of pancreas
Painless, slow
Filled w/ thick mucin
Lined by columnar mucin producing epithelium
- Gene mutated
- gender
Mucinous cystic neoplasms
KRAS
TP53 RNF43
female
Neoplasm in duct of pancreas
Mucin producing
Head of pancreas
- gene mutated
- gender
Intraductal papillary mucinous neoplasms (IPMNS)
GNAS KRAS
MALE
CTNNB1 leads to
B-catenin oncogene mutation leads to hyperactive WNT signaling
Large well circumsciried malignant neoplasm with solid cystic components filled w/ hemorrhagic debris
Tail
Grow insolid sheets
Solid pseudopapillary neoplasm
young women
