Ch18 - Adrenergic Drugs Flashcards

1
Q

Adrenergics are part of what CNS system?

A

Autonomic nervous system, sympathetic

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2
Q

Sympathetic system practices what kind of responses?

A

Fight/Flight

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3
Q

What kind of neurotransmitters do adrenergic receptors respond to?

A

Catecholamines: norepinephrine and epinephrine

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4
Q

Where are the alpha 1 receptors located?

A

Located on the post synaptic nerve

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5
Q

Where are the alpha 2 receptors located?

A

Located on pre synaptic cells

Tissue, muscle,organs, that the nerve stimulates

They control the release of neurotransmitters

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6
Q

Where are the beta 1 receptors located?

A

Post synaptic cells

Primarily in the heart

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7
Q

Where are the beta 2 receptors located?

A

Post synaptic cells

Primarily in smooth muscle, bronchioles, arterioles, visceral organs

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8
Q

What effects to beta 1 receptors have on the body?

A

Increase contraction
Increase heart rate
Increase conduction
Increase renin secretion

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9
Q

What effects do beta 2 receptors have on the body?

A

Bronchodilation

Decrease gi motility, decrease secretions, vasodilation( decrease b/p) , increase blood sugar

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10
Q

What do the dopaminergic receptors do to the body?

A

They only respond to catecholamine dopamine

Increase blood flow to brain, kidneys, viscera

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11
Q

Cholinergics are part of what CNS system?

A

Autonomic nervous system, Paraympathetic

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12
Q

Parasympathetic nervous system practices what kind of responses?

A

Rest/digest

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13
Q

What kind of neurotransmitters respond to cholinergic receptors?

A

Acetylcholine

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14
Q

What effects do muscarinic receptors have on the body?

A

Increase gi and bladder motility, increase secretions, constricts pupils, bronchoconstriction, decrease heart rate, contraction, and conduction

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15
Q

If a drug is blocking activation of a receptor it is called?

A

Antagonist

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16
Q

If a drug is activating a receptors binding it is called?

A

Agonist

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17
Q

What are sympathomimetics used for?

A

Mimicking the response of norepinephrine, epinephrine, and dopamine on receptors

18
Q

If a patient has asthma or bronchitis what kind of drug would you be giving them?

A

Beta 2 drugs for bronchodilation

19
Q

If a patient has nasal congestion what kind of drug would you give them?

A

Alpha 1 vasoconstriction of the nasal arterioles

20
Q

If a patient has conjunctival congestion or glaucoma what kind of drug would you give them?

A

Alpha 1/ and or beta 2 vasoconstriction of eye arterioles, pupil dilation

21
Q

What are some side effects of adrenergic agonists on the CNS?

A

Chest pain, heart palpitations, vasoconstriction, hypertension, dilation of pupils, decrease in reproductive, urinary contraction

22
Q

What are the actions of alpha blockers? (Antagonist)

A

Interrupt stimulation of sympathetic nervous system (inhibit)

23
Q

When alpha blockers interrupt stimulation what kind of effects on the body does that cause?

A

Arterial and venous dilation

Reduce b/p, lower heart rate

24
Q

A patient has necrotic skin by the iv insertion, what do you give the patient to hopefully save the affected area?

A

Alpha 1 blocker, it will dilate blood vessels allowing more flow of blood to affected area

25
Q

What kind of side effects could an alpha 1 blocker have?

A

Hypotension, increase fall risks

26
Q

What effect do beta 1 blockers have on the body?

A

Slows heart rate, slows conduction, contractility

27
Q

Define nonselective beta blockers.

A

Block both beta 1 and beta 2 drugs

28
Q

What effects do beta 2 blockers have on the body?

A

Bronchoconstriction : narrows airways, shortness of breath

29
Q

What kind of conditions would you give a beta blocker?

A

Angina- decreasing demand of heart to pump for oxygen

Myocardial infarction, hypertension, heart failure, dysthymia

30
Q

What kind of side effects could beta blockers cause?

A

Bradycardia, hypotension, bronchoconstriction, hypoglycemia

31
Q

What are the actions of a parasympathomimetic?

A

Mimic neurotransmitters acetylcholine (cholinergic agonist drug)

32
Q

What effects can you expect from a cholinergic agonist drug?

A

Increase gi motility, construction of pupil, decrease heart rate, construction of bronchioles, increase muscle contraction

33
Q

Direct acting cholinergic drugs do what?

A

Bind directly to cholinergic receptors

Usually treats glaucoma, drymouth, urinary retention

34
Q

Indirect acting cholinergics do what?

A

Stimulate release of acetylcholine to bind to receptors and activate reaction
Usually treats myasthenia gravis, Alzheimer’s

35
Q

What is the function of acetylcholinesterase?

A

Enzyme that breaks down acetylcholine

36
Q

In the Alzheimer’s disease what is happening with the neurotransmitters ?

A

Levels of acetylcholine have decreased

37
Q

What are the major side effects of cholinergic drugs? (SLUDGE)

A
Salivation
Lacrimation
Utinary
Diarrhea
GI cramps
Emesis
38
Q

Someone taking cholinergics should be cautious when?

A

Changing positions or moving..fall risk

39
Q

What are the actions of an anti cholinergic drug? (Antagonist)

A

Opposite of SLUDGE

decrease salivation
Decrease lacrimation
Urinary retension
Decrease diarrhea
Decrease gi motility
Decrease Emesis
40
Q

What should you look for in a patient when giving them an anti cholinergic drug?

A

Hydration

41
Q

Someone with Parkinson’s disease can expect what from receiving a anti cholinergic drug?

A

Decrease in muscle rigidity and tremors