Ch 15 - Antiparkinson Drugs

Question 1

Parkinson’s disease is?

Answer 1

A progressive neurological disorder affecting dopamine

Question 2

What is the theory of developing Parkinson’s disease?

Answer 2

An imbalance of dopamine and acetylcholine in the CNS

Question 3

Drug therapy for Parkinson’s disease is aimed at doing what?

Answer 3

Increasing the supply of dopamine in the brain, and/or blocking or lowering the acetylcholine levels

Question 4

What are some symptoms of Parkinson’s disease?

Answer 4

(TRAP) Tremors, Rigidity, Akinesia, Postural instability

Question 5

What kind of drug can be given to increase dopamine levels in the brain?

Answer 5

(Sinemet) car idols-levodopa

Question 6

What does carbidopa-levodopa do to increase dopamine levels?

Answer 6

They inhibit MAO enzymes from breaking down dopamine so there are more

Question 7

What enzymes prolong the action of levodopa?

Answer 7

Catechol- ortho methyltransferase (COMT)

Question 8

What are some side effects of antiparkinsons drugs?

Answer 8

Nausea, vomitting, arrhythmia, paranoia

Question 9

What kind of instructions would you give to someone taking an antiparkinsons disease drug?

Answer 9

Take with food 30 minutes before a high protein meal

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