Ch10, B cell development

Question 1

Development:
State the development of B cells using the following words: AG-independant phase, Naive B cell, encountering Ag (what happens).ss

Answer 1

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Question 2

Put these terms in order:
Common lymphoid progenitor, Pre-B, Mature B, Pro-B, Immature B, Expression of IGD and IGM, migration to lympoid follicles

Answer 2

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Question 3

What occurs in Pro-B and Pre-B and immature B stages?

Answer 3

Pro-B heavy chain rearrangement, Pre-B is light chain rearrangement, immature B has now committed to antegenic speceficity and produces IGM, only functional once both IGM and IGD are presented.

Question 4

Testing of B cells in bone marrow to ensure they work right, 3 possible outcomes.

Answer 4

1) Clonal deletion of strongly autoreactive cells through apoptosis (central tolerance)
2) receptor editing
3) anergy- induction of none responsiveness to further stimuli.