Ch. 8 - Geriatric Pharm Flashcards
Decreased Organ Function –>
- Monitor effect of drug therapy to prevent
- Risk of adverse reactions
- Possible drug toxicity
GI System (1):
Increase: PH gastric secretions
GI System (2):
Decreased:
- Peristalsis with delayed emptying time - Motility laxatives
Cardiac / Circulatory:
Decreased:
- cardiac output - Blood flow
Hepatic:
Decreased:
- enzyme function - Blood flow
Renal:
Decreased:
- blood flow - Functioning nephrons - Glomerular filtration Rate
Absorption (1):
- ) Slowed d/t: blood flow decrease
- ) Gi motility decrease
- ) Drugs remain in gi tract longer
Absorption (2):
Acidic drugs poorly absorbed d/t: -alkaline gastric secretion increase ------------------------------------------------------- Amount of dose absorbed -Not affected
Distribution (1):
Decreased protein binding sites for drugs:
- ) Increase amount of free drug in circulation
- ) Increase chance for adverse reaction
Distribution (2):
Loss of body water:
-decreased volume of distribution of water soluble drugs then drugs become more concentrated (not enough volume for drug to be distributed)
Distribution (3):
Total body fat increased:
-Fat-soluble drugs may be absorbed in fatty tissue and released slowly into bloodstream then decreases in desired drug affect
Metabolism (Biotransformation):
Decreased blood flow to liver:
- ) Decreased ability to metabolize and detoxify drugs
- ) Increased risk for drug toxicity
Excretion:
- ) Decreased cardiac output & blood flow throughout circulation
- ) Decreased renal functioning
- drug toxicity more likely
Pharmacodynamics:
- ) Lack of affinity to receptor sites throughout the body
2. ) May experience altered drug response
Barriers to Effective Medication Use (1):
Sensory losses:
- ) Difficulty reading labels
- ) Hearing loss