Ch. 7-Drug Delivery

Question 0

solutions

Answer 0

something is completely dissolved in a medium

-often oral or injection; or applied to nose, ears, or eyes

Question 1

4 dosage forms

Answer 1

solutions, dispersions, semisolids, solids

Question 2

dispersion

Answer 2

one phase dispersed in the medium of another phase

• “shake well before use”
• often oral or injection

Question 3

semisolids

Answer 3

things such as ointments, creams, and gels

Question 4

solids

Answer 4

most common dosage form

-tablets, capsules, powders

Question 5

how does solubility affect drug dissolution?

Answer 5

higher solubility makes the drug dissolve faster

Question 6

how does solid state structure affect drug dissolution?

Answer 6

a high energy polymorph has higher solubility

Question 7

how does pH of the medium affect drug dissolution?

Answer 7

weak acid dissolves faster in higher pH

weak base dissolves faster in lower pH

Question 8

how does the concentration gradient affect drug dissolution?

Answer 8

higher concentration gradient=higher solubility

lower concentration gradient=lower solubility

Question 9

how does particle size affect drug dissolution?

Answer 9

larger particles have lower solubility

Question 10

how does the diffusion coefficient affect drug dissolution?

Answer 10

a high molecular weight=low diffusion coefficient which equals low solubility

Question 11

how does diffusion layer thickness affect drug dissolution?

Answer 11

higher membrane thickness gives a lower solubility

Question 12

shelf life

Answer 12

period after manufacture during which a product is expected to perform as intended under recommended conditions
-same for all drugs

Question 13

expiration date

Answer 13

exact date after a product is no longer guaranteed safe and effective

Question 14

3 things that can happen by the expiration date

Answer 14

chemical degradation (gradual decline in safety and effectiveness)
contamination
physical changes (appearance, color, taste, etc)

Question 15

chemical stability

Answer 15

change in amount of active drug over time

Question 16

what can affect chemical stability?

Answer 16

certain temperatures and packaging, etc

Question 17

physical stability

Answer 17

change in physical characteristics affecting safety, effectiveness
-ex) drug shouldn’t crystallize on the bottom of the bottle