Ch 6: Lipids Flashcards
Lipid
Carbon containing compounds largely non polar and hydrophobic
Lipid= fat!
Defined by their solubility
Dehydration reactions
Join fatty acids to glycerol
Produce water
Fats
Consists of glycerol linked to 3 fatty acids by ester linkages
Amphipathic molecules
Both polar and non polar parts
- cholesterol
- phospholipid
- proteins
Lipid micelles and lipid bilayers
Form spontaneously even though decrease of entropy.
-serine and phosphate groups are polar hydrophilic parts on outside, interact with water
Permeability of bilayer
Gases (o2,co2,n2) = very permeable
Small uncharged polar molecules( water, indole, glycerol) = pretty permeable
Large, uncharged polar(sucrose, glucose) =semi/ not really permeable
Ions (cl-,k+,na+)= not permeable/ extremely slow
Unsaturated fatty acids
Have double bonds
Cause kinks in tails= higher permeability
Saturated lipids with long tails
Strong hydrophobic interactions= solid at room temp
Unsaturated lipids tend to be
Liquid (oils) at room temp
Amphoteric proteins can
Integrate into lipid bilayers
Sandwhich model
Membrane proteins on outside of bilayer
-dropped in favor of fluid mosaic
Fluid mosaic model
Membrane proteins integrated in bilayer
Freeze fracture experiment
Evidence supporting fluid mosaic
- strike frozen cell with knife
- fracture splits lipid bilayer (exterior membrane, middle membrane)
- observe middle of membrane=pits and mounds. Exterior contains only mounds
Lipids can act as Important signaling molecules
- Phospholipase C splits lipid at that interacts with ends reticulum
- opens calcium channel to release calcium