Ch. 56-Biology Of Keratinocytes

Question 1

What triggers terminal differentiation in keratinocytes in the suprabasilar laye?

Answer 1

Increased in intracellular calcium

Question 2

What layer does the formation of cornified cell envelope start?

Answer 2

Upper spinous

Question 3

What is the protein accounting for majority of cornified envelope mass?

Answer 3

Loricin

Question 4

What type of bond cross-links proteins in cornified envelope?

Answer 4

Epsilon-gamma-glutamyl lysine isopeptide bonds

Question 5

Which enzyme class is responsible for cross linking proteins in CE

Answer 5

Transglutaminases

TG-1, 2, 3 and 5

Question 6

Which keratins are Type 1? Acidic or basic?

Answer 6

Type 1 =acidic= K9-28, 31-40

Question 7

Which keratins are type II? Acidic or basic?

Answer 7

Basic

K1-8, 71-86

Question 8

Name 7 keratins in the medulla of the hair shaft?

Answer 8

Epithelial keratins: 17 and 75

Hair keratins: 33, 34, 36, 37, 81

Question 9

NAme the keratins of the cortex of the hair shaft

Answer 9

Type I-31-38

Type II-81, 83, 85, 86

Question 10

Name the 4 keratins of the hair cuticle

Answer 10

32, 35 with partners 82, 85

Question 11

Name the 3 keratins of inner root sheath

Answer 11

71, 73, 74

Question 12

Name 5 kerartins in outer root sheath

Answer 12

5/14 in full thickness

6, 16 and 17 in isthmus and lower ORS

Question 13

Name 10 keratins present in hair

Answer 13

31-38

71, 73, 74, 75

81, 83, 85, 86

5, 14

6, 16, 17