Ch. 40-Autoantibodies in rheumatic disease Flashcards
Most sensitive Ab in lupus
ANA
Most specific 3 antibodies in lupus
anti-dsDNA*
Anti-Sm*
rRNP (sometimes called just RNP/U1RNP-seen in MCTD)
Drug induced SLE? What %?
anti-histone
95%
What antibodies for disease activity
c3/c4
dsDNA
What % patients SLE + aNA
99%
What % patients dsDNA
60%
What is dsDNA associated with?
lupus nephritis
What % SLE + for anti smith
10-30% cause
30-40 asian and African American
30%
What % SLE + RNP
7-15%, 40% asians
RNP association
neuropsychiatric
What ANA pattern associated with SLE
Homogenous
Speckled
Peripheral
Name 10 antibodies seen in SLE
Specific:
dsDNA-60
Sm-30
RNP-30
B2 glycoprotein-25%
cardiolipin-50%
Less specific ANA-99 ssDNA -70% c1Q-60% Histone-40 % SSA-50% U1RNP-50% PCNA-50% ku SSB RF
What Ab is neonatal lupus associated with?
Anti-SSA/ro
What ab SCLE associated with?
SSA/ro
What Ab is drug induced SCLE associated with?
SSA/Ro
What ab associated with possible risk for SLE in DLE patients;
ssDNA
What is c1Q associated with
Hypocomplementemic urticarial vasculitis and severe SLE
What is mixed CTD
Lupus
Scleroderma
Polymyositis
What Ab associated with Mixed CTD? what % have it?
Anti-U1RNP (RNP sometimes called)
100%
What % DM ANA +
40%
What are the DM specific antibodies
Mi-2 Jo-1 (PL-7, PL-12, OJ, EJ) TIFF/P155 MDA5 NXP2 SAE1 SRP
What Ab’s in APLS
Anticardiolipin
B2-glycoprotein
lupus inhibitor/anticoagulant
True or false: Amyopathic DM is more associated with ANA + than myopathic?
True! Present in 65% amyopathic DM
Which 2 DM antibodies are clinically amyopathic
Tiff-1 gamma/p155
and
MDA5
What is DM with MI-2 + associated with? What % DM are mi-2 +?
15%
Myositis with proximal muscle weakness
Skin: Classic cutaneous DM
No malignancy association
What is features of DM with Jo-1 positivity? What %?
20%
Anti-synthetase syndrome
What Ab’s associated with anti-sdnthetase
Jo-1* PL-7 PL-12 OJ EJ
Does mechanics. hands occur in only anti-synthetase syndrome?
No. Occurs in amyopathic variants as well.
What is anti-sythetase syndrome
Mechanics hands
ILD
Raynauds
Arthritis
What is the other name for P155
TIF-1 gamma
What % DM patients are p155/TIFF-1 positive?
20–30% classic DM
80% of those who are amyopathic
Features of P155/TIFF-1 gamma DM?
- Clinically amyopathic 80% of the time
- highest risk malignancy
Skin:
- diffuse photo distributed erythema
- palatal erythema (“ovoid patches”)
- psoriasiform lesions
- keratotic palmar papules
- hypopigmented and telangiectatic (“red on white”) patches
- infrequent calcinosis
Anti-SRP features DM?
Fulminant DM/PM with cardiac involvement
Drug resistant PM
High mortality rate