Biology Of Wound Healing Flashcards
What is the difference between fetal and adult/children healing?
Regenerative process in fetal tissue= no scar
Vs.
Reparative process =scar
What are the 3 stages of wound healing?
Inflammation
Tissue formation
Remodeling
Name 5 factors that can lead to chronic non healing wounds?
Venous HTN
Atherosclerosis
Diabetes
Pressure
Infection
Inflammation
What is the most important cell type in wound healing?
Macrophages
How does persistent inflammation cause chronic wounds?
Increased protease activitity (MMPs, serine proteinases) and generation of ROS
What is a partial thickness wound?
Epidermis and portion of dermis
Superficial partial= epidermis and upper part of dermis
Deep partial= epidermis, papillary and part of reticular dermis, ADNEXAL structures remain
What is a full thickness wound?
Entire epidermis, dermis and extension into subcutaneous fat.
Loss of adnexal structures nd thus loss of source of keratinocytes for re-epitheliaztion
How do erosions heal?
Epidermal REGENERATION with no scarring
How do partial thickness wounds heal?
Re-epitheliazation occurs from wounds edges + remaining adnexal structures
Scar formation
How do full thickness wounds heal
Re-epitheliazation only from wound edges,
scar formation
wound contraction
*Size of a toonie is as far as they can travel, otherwise wont heal
What direction does wound contraction occur
In relation to skin tension lines
What is the downside to wound contraction?
Cosmetically disifguring contractures
Above what size does primary closure improve cosmetic outcome vs. Secondary intenion
8 mm and above
