Ch 4 : Tissue Radiation Biology Flashcards
T/F
Theoretically, all cells are radioresistant.
False,
Theoretically, all cells are radiosensitive
The function of an organ occurs at the ________ level.
Parenchymal
Which is not an example of a stromal cell?
- hepatocytes
- ligaments
- veins
- arteries
Hepatocytes
B/c stromal provides structure and support
What is the order of cell types from most sensitive to least sensitive?
VIM DIM Connective RPM FPM
On a cell survival curve, mature cells have _______ shoulder than immature cells.
A larger shoulder
T/F
Late responding effects to radiation are more likely to require surgical intervention than early responding effects.
True
Which of the following types of tissues is the most sensitive?
- bone marrow
- liver
- brain
- muscle
Bone marrow is the most sensitive b/c compared to the other options, it does NOT have a job specific function
Stem cells are most accurately describe as what type of cell Population?
VIM cell
VIM and DIM cells are most closely associated with ________ side effects of radiation
Acute side effects
T/F
Mature lymphocytes are radioresistant.
False. Mature lymphocytes are radiosensitive
T/F
In general, mature cells are radiosensitive
False, in general , mature cells are radioresistant with the exception of mature lymphocytes
Which is NOT considered an early response to radiation?
- nausea and vomiting
- diarrhea
- changes in urinary frequency
- tissue fibroids
Tissue fibroids
This is considered as a LATE response to radiation
Which of the following is the least radiosensitive?
- spermatogonium
- spermatid
- sperm
- spermatocytes
Sperm is the least radiosensitive
Place the following in order from most sensitive to least sensitive
(Sperm, spermatocytes, spermatid, spermatogonium )
Spermatogonium Spermatocytes Spermatid Sperm **Hint, spelling gets shorter as cells become least sensitive (more mature) **
Different cells have different radio-sensitivity. We can affect these sensitivities with _________ or _________.
Different drugs or Oxygen
These scientist defined radio-sensitivity in terms of mitotic activity, degree of sensitivity and proliferation of cells
Bergonie and Tribondeau
____________ (type therapy treatments)targets rapidly diving cells.
Chemotherapy and radiation therapy
(Undifferentiated or Differentiated)
Radiosensitive but cells regenerate and repair.
Undifferentiated
(Undifferentiated or Differentiated)
Insensitive (radioresistant) but cells does NOT regenerate or repair.
Differentiated
Who stated that cells have inherent sensitivity, not conditional ?
Bergonie and Tribondeau
Testes contains both _________ and _________
Testes contains both immature dividing and mature no dividing cells
Law of Bergonie and Tribondeau states that…..
Immature, dividing cells are more sensitive than mature, nondividing cells.
________________ defined 5 categories of cell population in terms of their radiation sensitivities and they focused on histologic signs of cell death, not the loss of proliferated potential.
Rubin and Casserett
What are the 5 categories of cell population, listing from most immature to most mature?
VIM (Vegetative Intermitotic) DIM (Differentiating Intermitotic) Connective (blood vessel and Connective Tissue) RPM (reverting Post mitotic) FPM (Fixed Post Mitotic)
What are VIM cells ?
VIM cells are rapidly dividing, undifferentiated cells that have a short lifetime. These cells are the most radio-sensitive and small amount of radiation will cause cell death either histologically or by mitosis
Examples of VIM cells
Basal cells of epidermis Crypt cells of intestines Type A spermatogonia Erythroblasts Stem cells
