Ch 3: Cell Survival Curve Flashcards
Non-mitotic death is synonymous with?
Interphase death
What happens in division delay?
Cells enter G0 and radiation is not effective
What happens in interphase death?
Cells do no need to enter into mitosis and death occurs via apoptosis
What happens in reproductive failure?
Death is not immediate but cells lose enough chromosome information that eventually cause cell death
Characterized by single strand breaks that can be repaired
(SLD) sub lethal damage
Dose is high enough to kill cells but cells may not be cycling and are therefore more likely to survive
(PLD) potentially lethal damage
If a radio-sensitizer is added to sparsely ionizing radiation, what happens to the survival curve?
The survival curve moves to the left
______ is defined as the dose required to reduce the fraction of cells surviving to 37 percent
Do
The slope of a cell survival irradiated with alpha particles is ______ than a survival curve irradiated with sparsely ionizing radiation
Steeper
The shoulder of the cell survival curve is formed by
(SLD) sub lethal damage
Dq is dependent on
Type of radiation damage (direct or indirect)
Cell type
Environmental conditions
With a plating efficiency of 90 percent, if 43 colonies of cells remaining after a dose of radiation is given to 1000 cells, what is the surviving fraction?
0.048
Radiation of neutrons or alpha particles exhibit _______ shoulder on the cell survival curves.
No
Programmed cell death is know as?
Apoptosis
How can you overcome division delay
By increasing radiation dose