Ch 3: Cell Survival Curve Flashcards

1
Q

Non-mitotic death is synonymous with?

A

Interphase death

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2
Q

What happens in division delay?

A

Cells enter G0 and radiation is not effective

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3
Q

What happens in interphase death?

A

Cells do no need to enter into mitosis and death occurs via apoptosis

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4
Q

What happens in reproductive failure?

A

Death is not immediate but cells lose enough chromosome information that eventually cause cell death

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5
Q

Characterized by single strand breaks that can be repaired

A

(SLD) sub lethal damage

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6
Q

Dose is high enough to kill cells but cells may not be cycling and are therefore more likely to survive

A

(PLD) potentially lethal damage

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7
Q

If a radio-sensitizer is added to sparsely ionizing radiation, what happens to the survival curve?

A

The survival curve moves to the left

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8
Q

______ is defined as the dose required to reduce the fraction of cells surviving to 37 percent

A

Do

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9
Q

The slope of a cell survival irradiated with alpha particles is ______ than a survival curve irradiated with sparsely ionizing radiation

A

Steeper

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10
Q

The shoulder of the cell survival curve is formed by

A

(SLD) sub lethal damage

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11
Q

Dq is dependent on

A

Type of radiation damage (direct or indirect)
Cell type
Environmental conditions

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12
Q

With a plating efficiency of 90 percent, if 43 colonies of cells remaining after a dose of radiation is given to 1000 cells, what is the surviving fraction?

A

0.048

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13
Q

Radiation of neutrons or alpha particles exhibit _______ shoulder on the cell survival curves.

A

No

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14
Q

Programmed cell death is know as?

A

Apoptosis

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15
Q

How can you overcome division delay

A

By increasing radiation dose

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16
Q

Division delay is:

When cell haven’t been killed, instead they are like being stunned. Cell will enter G0 phase, which will provided them enough time to recover from any damage from radiation

A

True

17
Q

In interphase death, cell does not need to undergo mitosis and cell death is from apoptosis or necrosis

A

True

18
Q

Reproductive failure is:

Is NOT immediate death, but cells can be considered dead b/c cells consequently have loss aspects of their chroma tins and chromosome and thus with each division, less info will be transmitted to daughter cell

A

True

19
Q

Dq is?

A

The shoulder, indicates ability to repair

20
Q

D0?

A

Dose required to reduce the fraction of cells serving to 37 percent. It is the sensitivity.

21
Q

Dq is dependent on?

A

Type of radiation (indirect or direct)

Cell type and cell condition

22
Q

The larger the shoulder , the larger the Dq, the more radiation is required to get equivalent amount of cell death

A

True

23
Q

How is D10 calculated?

A

2.3 times D0. Answer will be in Gy.

24
Q

What are the 2 distant terms for DNA damage

A

SLD

PLD

25
Q

PLD is when enough radiation is given to cause death but since the cell is NOT cycling, the damage cannot manifest fully

A

True

26
Q

SLD is measured by?

A

Dq; the shoulder; the Bailey to repair

27
Q

Example of a suboptimal condition in PLD

A

Hypoxia

Inadequate nutrient

28
Q

Densely ionizing (alpha and neutrons) is NOT impacted by O2, radiosensitizer or radioprotectors

A

True

29
Q

If you add radiosensitizer to sparsely ionizing, it will move to the ______.

A

Left

30
Q

If you add radioprotectors to the sparsely ionizing, it will move to the ______

A

Right

31
Q

Densely ionizing particles work through DIRECT damage, no slope means at any given dose wil cause DNA damage

A

True

32
Q

Sparsely ionizing works though INDIRECT.

A

True

33
Q

Low dose to densely will give same effect as sparsely

HIGH dose to sparsely will give same effect as densely

A

True

34
Q

As D0 increases, cell becomes ore resistant

A

True

35
Q

As DO decrease, cell become more sensitive

A

True