CH 4: Tissue Level Flashcards
tissue
integrated group of similar cells that usually have a similar embryological origin and are specialized for a specific function
cell junctions - definition
point of contact between adjacent cells - cells can be attached together or to the basement membrane or to the connective tissue
cell junctions - functions
- anchor cells together or to extracellular material (adherens junctions, desmosomes, hemidesmosomes)
- form fluid-tight seals between cells (tight junctions)
- act as channels that allow ions and molecules to pass from cell to cell (gap junctions)
CAMs
cell adhesion molecules: are transmembrane proteins that bind to each other and to the cytoskeleton
adherens junctions - structure
transmembrane integral proteins are attached to microfilaments in the cytoskeleton and to the integral membrane proteins of the other cell
made of:
- plaque: dense layer of proteins inside the cell membrane
- cadherins (integral membrane proteins): connect cell to cell
- microfilaments: anchor the cadherin in each cell forming adhesion belts
adherens junctions - function
hold cells together
ex. join epithelial cells together
desmosomes - structure
similar to adherens junctions, except that cadherins are anchored by intermediate filaments which cross the cytoplasm from one side of the cell to the othere
desmosomes - function
prevent separation of cells
ex. prevent separation of epidermal cell and cardiac muscle cells under tension
hemidesmosomes - structure
half a desmosome
transmembrane proteins are attached to intermediate filaments + the integrin (anchor protein) links to the protein laminin in the basement membrane
basal lamina - structure
=basement membrane
- thin layer of connective tissue underlying eputhelial tissue
- thin acellular extracellular membrane made of 2 layers:
- basal lamina: secreted by epithelial cells and composed of collagen fibers, laminin, various glycoproteins and proteoglycans
- reticular lamina: secreted by connective tissue cells and composed of reticular fibers
tight junctions - structure
the two plasma membranes are tightly fused together by interlocking membrane proteins
tight junctions - function
prevent passage of fluids (including water) across a tissue layer
tight junctions - location
line GI tract and bladder
gap junctions - structure
formed by channel proteins called connexins (two connexins=connexon) that span the membrane of two cells
it’s a tiny space between the plasma membranes of two cells
gap junctions - function
allow for passage of ions and small molecules between cells, enabling cells to communicate
gap junctions - location
in heart and smooth muscle of the gut
- gap junctions in the heart allow the cardiac muscle cells to beat in sync
tissue types
- epithelial
- muscle
- connective
- nervous
epithelial tissue - purpose
- covers and lines surfaces
- provides selective barriers for movement of material
ex. barrier btw body and environment (skin, gut)
ex barrier btw different structures (blood vessels)
- provides protection from damage/abrasion
- absorbs nutrients (gut) - forms secretion portions of glands
- produces mucus, hormones and enzymes
epithelial tissue - structure
- cells closely packed together (with cell junctions) with intracellular space
- cells sit on basement membrane
- consists of apical surface and basal surface
1. high rate of cell turnover/cell regeneration
2. has its own good nerve supply
3. avascular: relies on diffusion from blood blood vessels withing connective tissue from removal of waste and nutrient delivery
basement mebrane - function
attachment and support for epithelial tissue
apical surface
“free” surface - epithelial tissue
- region exposed to space inside the organ or lumen
basal surface
adheres to basement mebrane - epithelial tissue
basal lamina
layer of basement mebrane
- secreted by epithelial cells
- composed of collagen fiber, laminin, various glycoproteins and proteoglycans
reticular lamina
layer of basement membrane
- secreted by connective tissue
- composed of reticular fibers
epithelial cells - features
- microvilli: increase SA (digestive, urinary and reproductive tracts)
- cilia: found in portions of the respiratory and reproductive tracts
- apical surface: region exposed to space inside the organ and lumen
- basal surface: attaches to underlying epithelial cells or deeper tissues
epithelial tissue - classification
- number of cell layers
- shape of cells
epithelial tissue - classification based on number of cell layers
- simple
- pseudostratified
- stratified
simple (epithelial tissue)
have single layer of cells
pseudostratified (epithelial tissue)
have single layer but irregular cell shape and nucleus
stratified (epithelial tissue)
have at least two layers of cells
- basal cells replicate by mitosis and replace more superficial layers
epithelial tissue - function
structure determines function
- material exchange
- simple squamous epithelium - secretion and absorption of material
- simple cuboidal epithelium
- simple columnar epithelium - protection
- stratified squamous epithelium
- pseudostratified ciliated columnar epithelium
simple squamous epithelium
- single layer of flat cells
- thin: adapted for diffusion (lungs, blood, lymph vessels) and filtration (kidneys)
- specific name in some organs:
- endhothelium: lines blood vessels
- endocardium: lines chambers of heart
- mesothelium: lines serous membranes
simple squamous epithelium - function
- diffusion (lungs, blood, lymph vessels)
- filtration (kidneys)
endothelium
simple squamous epithelim that lines blood vessels
endocardium
simple squamous epithelium that lines chambers of the heart
mesothelium
simple squamous epithelium that lines serous membranes
stratified squamous epithelium - structure
two or more layers of cells
- apical cells are flat
can be keratinized and non-keratinized
non-keratinized stratified squamous epithelium - location
lines moist surfaces:
- mouth
- esophagus
- part of epiglottis
- part of pharynx
- vagina
keratin
tough, fibrous intracellular protein found in skin, hair and nails
keratinized stratified squamous epithelium - location
superficial layer of skin
simple cuboidal epithelium - structure
one layer of cube-shaped cells
- nucleus: round and centered
simple cuboidal epithelium - function
absorption and secretion
simple cuboidal epithelium - location
lines kidney tubules, thyroid gland
stratified cuboidal epithelium- structure
two or more layers of cells
- cells in apical layer are cube-shaped
stratified cuboidal epithelium- location
in some ducts:
- sweat glands
- male urethra
- esophageal ducts
simple columnar epithelium - structure
single layer of column-shaped cells
- oval nuclei usually located near the base of cells
simple non-ciliated columnar epithelium - structure
contain microvilli at apical surface and goblet cells (secrete mucus)
goblet cells - function
secrete mucus
simple non-ciliated columnar epithelium - function
secretion and absorption
simple non-ciliated columnar epithelium - location
mucus secretion lubricates:
- GI
- respiratory
- reproductive
- urinary systems
simple ciliated columnar epithelium - structure
single layer of column-shaped cells with cilia on apical surface
- nucleus: oval, located near the base of the cell
usually contain interspersed goblet cells
simple ciliated columnar epithelium - function
cilia beat in unison to move fluid, mucus and/or foreign particles
simple ciliated columnar epithelium - location
line:
- bronchioles
- uterine tubes
- paranasal sinuses
- central canal of the spinal cord
- brain
pseudostratified columnar epithelium - structure
- single layer of columnar cells
- appears layered because nuclei are at different levels
- all cells are attached to the basement membrane
- not all cells reach the apical layer
pseudostratified columnar non-ciliated epithelium - structure
lacks goblet cells
no cilia
pseudostratified columnar non-ciliated epithelium - location
lines epididymis, ducts of larger glands and parts of male urethra
pseudostratified columnar non-ciliated epithelium - function
absorption and secretion
pseudostratified ciliated columnar epithelium - structure
contain cells with cilia or goblet cells (secrete mucus)
pseudostrlatified ciliated columnar epithelium - location
lines airways of upper respiratory tract
pseudostratified ciliated columnar epithelium - function
secretion and protection
stratified columnar epithelium - structure
- has at least two layers of cells
- apical layer has column-shaped cells
- cells in other layers can be short or irregularly shaped
stratified columnar epithelium - location
lines part of the urethra, esophageal and salivary gland ducts
stratified columnar epithelium - function
protection and secretion
transitional epithelium - structure
variable/transitional appearance
- relaxed state: looks like stratified cuboidal epithelium but has large and round apical cells
- stretched state: looks like stratified squamous epithelium as cells flatten
relaxed state
of transitional epithelium: looks like stratified cuboidal epithelium but has large and round apical cells
stretched state
of transitional epithelium: looks like stratified squamous epithelium as cells flatten
transitional epithelium - location
lines urinary bladder and portions of ureters and urethra
transitional epithelium - function
protection and ability to stretch within
grandular epithelium
- exocrine glands
- endocrine glands
exocrine glands - function
cells that secrete a product (mucus, sweat, ear wax, saliva, digestive enzymes, …) onto the free surface of the epithelial layer
- connected to surface by ducts (tubes)
exocrine glands - examples
- goblet cells
- sudoriferous
- sebaceous
- salivary glands
endocrine glands - function
secrete hormones into the interstitial fluid followed by diffusion to the bloodstream