CH 4: Tissue Level Flashcards
tissue
integrated group of similar cells that usually have a similar embryological origin and are specialized for a specific function
cell junctions - definition
point of contact between adjacent cells - cells can be attached together or to the basement membrane or to the connective tissue
cell junctions - functions
- anchor cells together or to extracellular material (adherens junctions, desmosomes, hemidesmosomes)
- form fluid-tight seals between cells (tight junctions)
- act as channels that allow ions and molecules to pass from cell to cell (gap junctions)
CAMs
cell adhesion molecules: are transmembrane proteins that bind to each other and to the cytoskeleton
adherens junctions - structure
transmembrane integral proteins are attached to microfilaments in the cytoskeleton and to the integral membrane proteins of the other cell
made of:
- plaque: dense layer of proteins inside the cell membrane
- cadherins (integral membrane proteins): connect cell to cell
- microfilaments: anchor the cadherin in each cell forming adhesion belts
adherens junctions - function
hold cells together
ex. join epithelial cells together
desmosomes - structure
similar to adherens junctions, except that cadherins are anchored by intermediate filaments which cross the cytoplasm from one side of the cell to the othere
desmosomes - function
prevent separation of cells
ex. prevent separation of epidermal cell and cardiac muscle cells under tension
hemidesmosomes - structure
half a desmosome
transmembrane proteins are attached to intermediate filaments + the integrin (anchor protein) links to the protein laminin in the basement membrane
basal lamina - structure
=basement membrane
- thin layer of connective tissue underlying eputhelial tissue
- thin acellular extracellular membrane made of 2 layers:
- basal lamina: secreted by epithelial cells and composed of collagen fibers, laminin, various glycoproteins and proteoglycans
- reticular lamina: secreted by connective tissue cells and composed of reticular fibers
tight junctions - structure
the two plasma membranes are tightly fused together by interlocking membrane proteins
tight junctions - function
prevent passage of fluids (including water) across a tissue layer
tight junctions - location
line GI tract and bladder
gap junctions - structure
formed by channel proteins called connexins (two connexins=connexon) that span the membrane of two cells
it’s a tiny space between the plasma membranes of two cells
gap junctions - function
allow for passage of ions and small molecules between cells, enabling cells to communicate
gap junctions - location
in heart and smooth muscle of the gut
- gap junctions in the heart allow the cardiac muscle cells to beat in sync
tissue types
- epithelial
- muscle
- connective
- nervous
epithelial tissue - purpose
- covers and lines surfaces
- provides selective barriers for movement of material
ex. barrier btw body and environment (skin, gut)
ex barrier btw different structures (blood vessels)
- provides protection from damage/abrasion
- absorbs nutrients (gut) - forms secretion portions of glands
- produces mucus, hormones and enzymes
epithelial tissue - structure
- cells closely packed together (with cell junctions) with intracellular space
- cells sit on basement membrane
- consists of apical surface and basal surface
1. high rate of cell turnover/cell regeneration
2. has its own good nerve supply
3. avascular: relies on diffusion from blood blood vessels withing connective tissue from removal of waste and nutrient delivery
basement mebrane - function
attachment and support for epithelial tissue
apical surface
“free” surface - epithelial tissue
- region exposed to space inside the organ or lumen
basal surface
adheres to basement mebrane - epithelial tissue
basal lamina
layer of basement mebrane
- secreted by epithelial cells
- composed of collagen fiber, laminin, various glycoproteins and proteoglycans
reticular lamina
layer of basement membrane
- secreted by connective tissue
- composed of reticular fibers