Ch 4- Physiology Of Cells Flashcards
Active transport
Movement that requires energy (ATP) from the cell. “Uphill” Moves from low concentration to high concentration.
Passive transport
Movement that does not require energy from the cell. Molecules use their own energy. “Downhill”. High to low concentration.
Enzyme
Functional proteins. Catalysts that speed up chemical reactions.
Substrate
Is the substance a specific enzyme acts on. Most enzymes act on only one substrate.
Metabolism
Anabolic and catabolic reactions. All the chemical reactions going on in the body.
Diffusion
Passive transport. Tendency of small molecules to spread out evenly in a given space. “Down the concentration gradient.”
Dialysis
Passive transport. The separation of smaller (diffusible) particles from larger (not diffusible) particles through a semipermeable membrane.
Osmosis
Passive transport. Diffusion of water through a selectively permeable membrane. From high to low concentration gradient.
Facilitated diffusion
Diffusion through carrier proteins in cell membranes. Use carrier molecules, no energy. From high to low concentration. Faster than any other types of diffusion. Passive transport.
Filtration
Water and permeable so lutes move through a membrane due to hydrostatic pressure.
Isotonic solution
Same water concentration on both sides of the membrane. Cell stays the same.
Hypotonic solution
Solutions that cause a cell to swell and even burst due to intake of water.
Hypertonic solution
Solutions that cause a cell to shrivel or shrink due to loss of water.
Active transport carrier mechanisms
Membrane transporters or membrane pumps move molecules against the concentration gradient. Examples: calcium pumps in muscles, sodium/potassium pumps in nerves.
Endocytosis
Engulfing large particles into the cell.
Exocytosis
Expelling large particles out of the cell.
“Lock and key” model
Deals with enzymes. Describes the physical fit of an active site and substrate.
How are enzymes named?
…ase ending after the substrate like…lipase, protease, lactase…
Some older ones have different names like pepsin and trypsin.
They may also be in general groups according to the types of reactions they speed up like digestive enzymes and hydroplanes.
Allosteric effectors
Activate or inhibit enzymes by changing their shape.
Examples: pH, temperature, drugs, other control molecules, cofactors like some vitamins.
Describe the importance of enzymes in metabolic pathways.
Metabolic pathways involve many enzymes.
Equation for cellular respiration
C6H12O6 + O2 —-> CO2 + H2O + energy
This is where most of our body heat comes from. We get energy in the form of 36 ATP and heat.
Cellular respiration step 1
Glycolysis - anaerobic, takes place in cytoskeleton.
Glucose broken down to 2 pyruvic acid and nets 2 ATP’s and m
NADH.
Cellular respiration step 2
Citric acid cycle- aerobic, takes place in the mitochondria.
Pyruvic acid enters the cycle attached to CoA….chops off CO2….releases NADH.
NADH stores high energy electrons.
Cellular respiration step 3
Electron transport system. On mitochondrial membranes. Aerobic.
NADH gives up energy as it changes to NAD+.
That energy is used to make more ATP.
Cystic fibrosis
Genetic disorder. (Cl pump damage)
Inherited disease involving abnormal Cl- ion transport; causes secretion of abnormally thick mucus and other problems.