CH 4 Pharmacodynamics Flashcards
Drug that activates a receptor and produces the same type of response as the endogenous substance:
Agonist
Agent that blocks the response of another drug:
Antagonist
The way a patient responds to varying doses of a drug:
Dose-response relationship
The maximal response that can be produced from a particular drug:
Efficacy
A graphic representation of the actual number of patients responding to a particular drug action at different doses:
Frequency distribution curve
The ability of a drug to bind to a receptor and produce a strong action:
Intrinsic activity
The amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that produces a therapeutic effect in 99% of the animals (ED99):
Margin of safety (MOS)
The dose of a drug required to produce a specific therapeutic response in 50% of a group of patients:
Median effective dose (ED50)
The dose of a drug that will kill 50% of a group of animals:
Median lethal dose (LD50)
The dose that will produce a given toxicity in 50% of a group of patients:
Median toxicity dose (TD50)
Medication that produces a weaker, or less efficacious, response than an agonist:
Partial agonist
Study of the mechanisms of drug action and how the body responds to drugs:
Pharmacodynamics
The study of genetic variations that alter patients’ responses to medications; branch of pharmacology that examines the role of genetics in drug response:
Pharmacogenetics
The strength of a drug at a specified concentration or dose:
Potency
Cellular molecule to which a drug binds to produce its effects:
Receptor
