Ch. 36 & 4 Flashcards
alzheimer’s disease
- unknown cause
- most common type of dementia
alzheimer’s disease: pathophysiology
structural changes in the brain
risk factors of alzheimer’s
- age: over 65
- gender: females
- genetics: familial history
there is a higher incidence and prevalence of alzheimer’s after age
65
alzheimer’s can affect anyone older than age
40
how many people are affected by alzheimer’s in the U.S.?
> 6 million (over 65 years)
is there a proven way to prevent alzheimer’s?
no- there is no proven way to prevent AD
what may contribute to alzheimer’s?
chronic health problems
- diabetes
- acrosclerosis
alzheimer’s: health promotion
- diet
- exercise
- stop drinking and smoking
alzheimer’s assessment: history
- onset (gradual onset of symptoms),
- duration,
- progression,
- course of sx
- functional assessment
alzheimer’s assessment: physical assessment
- 3 clinical stages (early, middle, late)
- changes in cognition
- attention and concentration
- judgement and perception,
- learning and memory,
- communication and language,
- information processing
alzheimer’s assessment includes
- history
- physical assessment
- psychosocial assessment
- laboratory and imaging assessment
alzheimer’s assessment: laboratory and imaging assessment
- brain tissue examination at autopsy is only definitive diagnosis
- diagnosis based on patient history and clinical presentation and imaging:
- PET scan
- MRI, CT scan
- genetic testing
what is the only definitive diagnosis of alzheimer’s?
brain tissue examination at autopsy
- therefore cannot “definitively” be diagnosed until after death
the priority collaborative problems for patients with alzheimer’s disease include:
- decreased memory and cognition r/t neuronal degeneration in the brain
- potential for injury or falls r/t wandering or inability to ambulate independently (think fires)
- potential for elder abuse by caregivers r/t patient’s prolonged progression of disability and the patient’s increasing care needs
the priority for interprofessional care of a patient with alzheimer’s is
safety
planning and implementation: what do we do as nurses for patients with alzheimer’s?
- manage memory and cognitive dysfunction
- nonpharmacologic interventions
- drug therapy
- prevent injuries and accidents
- prevent elder abuse
drug therapy for alzheimer’s includes
- cholinesterase inhibitors: donepezil
- NMDA receptor antagonist: memantine
care coordination and transition management of alzheimer’s includes
- home care management
- self-management education
- health care resources
alzheimer’s: home care management
- respite care
- caring for caregiver
alzheimer’s: self-management education
- emphasize mobility
alzheimer’s: health care resources
- Safe Return Program
evaluation of care for a patient with alzheimer’s includes:
- evaluating expected outcomes
- did the patient achieve these outcomes or do you need to revise the plan of care?
parkinson’s disease
- progressive neurodegenerative disease
what (neurologically) causes parkinson’s?
degeneration of the substantia nigra leads to decrease in dopamine levels in brain and affects mobility
parkinson’s disease is separated in ___ stages
5 stages
- stage 1 is mild progressing to stage 5 which is completely dependent
the 4 cardinal symptoms of parkinson’s
- tremor
- muscle rigidity
- bradykinesia (slow movement/speed)
- postural instability
parkinson’s: etiology (causes)
- environmental and genetic factors
- exposure to chemicals and metals
- older than 40 years old
- familial tendency
how many new cases of parkinson’s are seen annually in people over 50 years old?
60,000 new cases
how many people live with parkinson’s?
1 million
what is the prevalence of parkinson’s in men compared to women?
50% more men than women have PD
parkinson’s assessment includes
- history
- physical assessment
- laboratory and imaging assessment
parkinson’s assessment: history
- when symptoms started
parkinson’s assessment: physical assessment
- resting tremors in upper extremities
- rigidity assessment
- facial expression (“masklike”)
- emotional changes (depression)
- speech changes (slower, monotone, slurred, nonverbal)
- bowel and bladder changes (constipated/incontinent)
parkinson’s assessment: laboratory and imaging assessment
- no specific diagnostic tests
- may do a CSF, MRI, or SPECT
- autopsy
appearance of a patient with parkinson’s
- blank facial expression
- forward tilt to posture
- short, shuffling gait
- tremor
- slow, monotonous, slurred speech
planning and implementation: what do we do as nurses for patients with parkinson’s?
- promote mobility
- surgical management
- nonsurgical management- need to collaborate with multiple disciplines to plan care
- manage cognitive dysfunction
nonsurgical management of parkinson’s
- exercise and ambulation
- self-management
- injury prevention
- nutrition
- communication
- psychosocial support
- drug therapy
drug therapy for parkinson’s
- levodopa with carbidopa is often the first drug used
- dopamine receptor agonsits: ropinirole, pramipexole, bromocriptine
- catechol O-methyltrasferases (COMTs): entacapone
- monoamine oxidase B inhibitors: selegiline
what is often the first drug used for parkinson’s?
levodopa with carbidopa
dopamine receptor agonists used for parkinson’s
- ropinirole
- pramipexole
- bromocriptine
cetechol O-methyltrasferses (COMTs) used for parkinson’s
- entacapone
monoamine oxidase B inhibitors for parkinson’s
- selegiline
anticholinergics can be used in management of
parkinson’s disease- severe tremors and rigidity
- Benzotropine
anticholinergics should be used cautiously in older adults because
side effects of acute confusion, urinary retention, and dry mouth
BEERS CRITERIA
tool used to improve medication safety in older adults
- created by American Geriatric Society (AGS)
- medications that need to be used with caution due to severe side effects
what drug class do we give parkinson’s patients that is on BEERS?
- anticholinergics are on the BEERS CRITERIA list to try to avoid
parkinson’s: long-term drug therapy regimens often cause
- delirium
- cognitive impairment
- decreased effectiveness of the drug
- hallucinations
preventing drug tolerance/toxicity with parkinson’s meds
- reduce med dose
- change meds or frequency of administration
- take “drug holiday” especially in the use of levodopa therapy
“drug holiday” means
an agreed cessation of medication for a period of time
surgical management of parkinson’s disease
- last resort
- stereotactic pallidotomy
- deep brain stimulation
- experimental research- Fetal tissue transplantation (human deceased fetus or pig)