Ch 3: Neuroprotection & Neuroplasticity

Question 1

What is neuroptotection?

Answer 1

Compound or strategy that limits neuronal death following injury and/or enhances recovery

None approved for human tx of TBI & 1 for CVA (ie: tPA)

Question 2

Neuroplasticity

Answer 2

The ability of the nervous system to change itself, to form new connections and create new neurons in order to compensate for injury or adapt to changes in the environment

Question 3

Synaptogenesis

Answer 3

The greater the number of synapses within a grouping of neurons, the greater the speed and efficiency with which those neurons communicate.

Within neuronal network, new synapse formation is critical, and a key aspect of new synapse formation is the dendrite.

Question 4

Exicitotoxicity

Answer 4

Occurs when a neuron cannot maintain its resting potential, resulting in it’s repeated firing.

This creates toxic levels of sodium and calcium ions, leading to cell death.

Question 5

Transcranial magnetic stimulation (TMS)

Answer 5

Noninvasive method of stimulating the brain using electromagnetic induction.

It is used as a treatment modality for depression, stroke, migraines, dystonia, tinnitus, and Parkinson’s disease.