Ch. 21 Pharmacology Flashcards
What are drugs?
substances used to prevent or treat a condition or disease
Where are drugs obtained from?
plants, animals, they can be synthesized in a lab
Where do vitamins come from?
plant or animal sources and they are contained in foods
Pharmacist
an individual who is responsible preparing and dispensing drugs
Pharmacy
a storefront where drugs are prepared and dispensed
Via what way is a pharmacist allowed to dispense a prescription medication?
a written order from a physician
What is the written order referred to as written from a physician?
prescription
How long does it take to become a pharmacist?
most colleges offer a pharmacy degree and it takes about 6 to 7 years
What else are pharmacists responsible for?
consulting with and advising licensed practitioners about drugs; answering questions from the patient about their prescription
Pharmacy technician
can help licensed pharmacists by providing medication and other products to the patient
Pharmacology
the study of the discovery, properties, uses, and actions of drugs
What 2 things can a pharmacologist be?
a MD, who is a doctor of medicine, who actually went to medical school and completed an internship and residency
or
a PhD, a doctor of philosophy meaning the person has obtained a bachelor’s, masters, and doctoral degree, more of an academic doctorate
Chemotherapy
study of drugs that destroy microorganisms, parasites, or malignant cells within the body
treatment of choice for infectious diseases and cancer
Toxicology
study of harmful effects of drugs and chemicals on the body
Toxicologists
interested in finding antidotes that are appropriate for specific harmful effects of drugs
What is the purpose of an antidote?
to neutralize the effects of a drug
What are the 3 names a drug can have?
chemical name
generic name
brand name
What is the chemical name?
what specifies the exact chemical formula of the drug; often a very long and complicated name
What is the generic name?
shorter and less complicated and it identifies the drug legally and scientifically
only 1 generic name for each drug
What is a brand name or trade name?
the trademark, the private property if the individual drug manufacturer and no competitor may use it
What does a brand name have on it to show it’s been registered?
a superscript “R” with a circle around it
What is capitalized in the brand name?
first letter of the brand name, whereas generic names are not
Food and Drug Administration (FDA)
entity in the United States that has the legal responsibility for deciding whether a drug may be sold
United States Pharmacopeia (USP)
an independent committee of physicians, pharmacologists, pharmacists, and manufactures that reviews the available commercial drugs and continually reappraises their effectiveness
What are the 3 important standards of the USP?
Drug must be safe
Drug must be clinically useful (effective for patients)
Drug must be available in pure form (made by good manufacturing methods)
Hospital Formulary
most complete and up-to date listing which gives information about characteristics of drugs and their clinical usage (application to patient care ) as approved by that particular hospital
Physician’s Desk Reference (PDR)
published by a private firm, and drug manufacturers pay to have their products listed
What does the PDR provide?
useful reference with several different indices to identify drugs
with a complete description of the drug properties and approved indications
gives precautions, warnings about side effects
information about the recommended dosage and administration of each drug
Oral Administration
the most common and indicates the drug can be given by mouth; slowly absorbed into the bloodstream through the stomach or intestinal wall
Sublingual Administration
pertaining to below the tongue
drugs are placed under the tongue and dissolve in the saliva so absorption is rapid
What are nitroglycerin tablets administered for?
under the tongue to treat attacks of angina (chest pain)
Rectal Administration
administering drugs through a suppository, a cone-shaped object containing drugs
What type of solutions are inserted into the rectum?
aqueous
Why would one administer drugs via the rectum?
when oral administration presents difficulties like the patient is nauseated and vomiting
Parenteral Administration
process of injection of a drug using a syringe (tube) through a hollow needle placed under the skin into a muscle, vein, or body cavity
Intracavitary instillation
injection made into a body cavity, such as the peritoneal or pleural cavity
Intradermal injection
shallow injection that is made into the upper layers of the skin, used in skin testing for allergic reactions
Subcutaneous (hypodermic) injection (subQ)
when a small hypodermic (pertaining to below the skin) needle is introduced into the subcutaneous tissue under the skin
What are the typical areas for a subcutaneous injection?
upper arm, thigh, or abdomen
Intramuscular injection (IM)
when the buttocks or upper arm is the usual site for injection into muscle
when drugs are irritating to the skin or large volume of solution must be administered
Intrathecal instillation
when instillation occurs in the space under the membranes (meninges) surrounding the spinal cord and brain
way to introduce treatment for leukemia
Intravenous injection (IV)
injection is given directly into the vein
used for immediate effect from the drug is desired or when drug cannot be safely introduced into other tissues
Which type of injection requires some technical skill to make sure the drug gets into the vein and it doesn’t leak into the surrounding tissues which may result in irritation and inflammation?
Intravenous injection (IV)
Pumps
battery-powered, can be used for continuous administration of drugs by the subcutaneous or intravenous route; automated
Inhalation
vapors or gases are taken into the nose or mouth and are absorbed into the bloodstream via thin walls or air sacs in the lungs
What are particles of drug suspended in the air and are administered by inhalation like many anesthetics?
aresols
Topical Application
when drugs are applied locally on the skin or mucous membranes of the body
What are some examples of topical application?
antiseptics
antipruritics
transdermal patches
Antispetics
fight infection
Antipruritics
fight against itching, commonly ointments, creams, and lotions applied to the skin
Transdermal Patches
used to deliver drugs continuously through the skin like estrogen for hormone therapy, pain medications, and nicotine for smoking
What are administered orally?
caplets
capsules
tablets
What are administered sublingual?
tablets
What are administered rectal?
suppositories
What are administered parenteral?
injections and instillations
intracavitary
intradermal
intramuscular (IM)
intrathecal
intravenous (IV)
subcutaneous (subQ)
What are administered inhalation?
aerosols
What are administered topical?
lotions
creams
ointments
transdermal patches
Receptor
target substance with which the drug interacts to produce its effects
Dose of a drug
the amount of a drug administered, usually in milligrams or grams
Schedule
the exact timing and frequency of drug administration
Additive Action
2 similar drugs that are combined to equal the sum of the effects of each
If 2 drugs give less than an additive effect they are called….
antagonistic
If 2 drugs produce greater than additive effects
synergistic
Synergism
when combination of 2 drugs sometimes can cause an effect that is greater than the sum of the individual effects of the drug given alone
1+1=3
Response
desired and beneficial effect of a drug
Ex: lowering BP by antihypertensive drugs
Tolerance
effects of a given dose diminish as treatment continues and increasing amounts are needed to produce the same effect
Addiction
the physical and psychological dependence on and craving for a drug and the presence of clearly unpleasant effects when that drug or other agents is withdrawn