Ch. 2: Physical and Electrical Properties of Cells in the Nervous System Flashcards

1
Q

On a neuron:

What is the cell body called?

A

Soma

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2
Q

On a neuron:

What is the “reciving” antenna called?

A

Dendrite

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3
Q

On a neuron:

Where are new action potentials generated?

A

Axon Hilock

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4
Q

On a neuron:

What is the “transmitting antenna?”

A

Axon

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5
Q

On a neuron:

Where do parts of two neourns come together?

A

Synapse

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6
Q

On a neuron:

What is the end of an axon called when it connects with the next neuron?

A

Presynaptic Terminal

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7
Q

On a neuron:

What is the space called where chemical signaling occurs?

A

Synaptic Cleft

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8
Q

On a neuron:

What is the dendrite called that recieves chemical signals?

A

Postsynaptic membrane

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9
Q

What are the 4 general functions of nerve cells?

A
  1. Reception: receive signals
  2. Integration: gather many inputs and boil down to a majority opinion.
  3. Transmission: Transmit new signals electrically and chemically to other cells
  4. Transfer: transfer messages to other neurons across the synapse
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10
Q

What is the name of this neuron?

A

Bipolar

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11
Q

What is the name of this neuron?

A

Pseudo-Unipolar

(sensory neurons of the peripheral nervous system)

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12
Q

What is the name of this neuron?

A

Multipolar

(motor)

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13
Q

Transmission of info ALONG one neuron is _______

A

electrical

(within)

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14
Q

Transmission of info BETWEEN neurons _______

A

Chemical and electrical

(between)

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15
Q

What is a Nongated channel?

A
  • structural gate that it always open
  • Always leaking ions depending on relative concentrations or charge gradient
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16
Q

What is a Modality-Gated channel:

A
  • Touch or temperature
  • Primary modalities that cause them to open
  • @ distal end of sensory neurons
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17
Q

What is a Ligand-Gated channel?

A
  • “Protein”
  • Ligands that open these channels are neurotransmitters
  • On dendrites & bodies of nerve cells
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18
Q

What is a Voltage-Gated channel?

A
  • Responds to charge in membrane voltage
  • When -70mV changes it allows these gates to open
  • @ axon hilock of multipolar celss (most often) & near distal end of puedo-unipolar cells
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19
Q

What must exsit across cell membranes to create an “excitable” cell?

A

Potential Difference

(difference in charge)

20
Q

What factors maintain “resting potential” across a membrane?

A
  • Na+/K+ (3 Na+ out for every 2 K+ in)
  • Large negative molecules trapped in soma
  • Passive diffusion through non-gated channels
21
Q

What is Depolarization?

A

Cell becomes:

  • Less negative
  • More excited
  • More likely to create action potential
22
Q

What is Hyperpolarization?

A

Cell becomes

  • More negative
  • More Inhibited
  • Less likely to create an action potential
23
Q

What characterizes a local (change in) potential?

A
  • Modality and Ligand-Gated channels
  • “Receptor” and “Synaptic”
  • Small changes in polarity
  • Graded (can sum)
  • Larger stimulus or more transmitter equals bigger change in polarity
  • Depolarizing or hyperpolarizing
  • “Passive” propagation
  • Travel short distances
  • “Do I want to send a message or not?”
24
Q

What characterizes an action potential?

A
  • Voltage-Gated channels
  • “Action”
  • Large changes in polarity
  • All or none (can’t sum)
  • Larger stimulus or more transmitter equals more frequent action potentials
  • Depolarizing
  • “Passive” and “Active” propagation
  • Travel long distances
  • Message is sent
25
What is a Receptor (change in) potential?
Generated by modality-gated channels at distal end of sensory neurons
26
What is a Synaptic (change in) potnetials?
Generated by ligand-gated channels on post-synaptic membrane
27
What is a Temporal Summation?
* Repetitive opening of a channel * Open gate over and over, ions will spill, change in potential gets bigger
28
What is a Spatial Summation
29
What is the sequence from local potential to action potential?
1. Local potential (receptor or synaptic) reaches area with large #'s of voltage-gated channels 1. trigger zone - receptor potentials 2. Axon hillock - synaptic potentials 2. "Threshold" depolarization -\> open voltage-gated channels 3. Action potential -\> full depolarization - repolarization 4. Refractory period (temporary hyperpolarization) 5. Propagation
30
What is passive propagation?
spilling of ions
31
What is active propogation?
regeneration opening of new voltage gated channel downt he membrane (How action potentials travel)
32
What prevents an action potential from moving backwards?
Refractory period
33
What is saltatory conduction?
Action potential jumps from one Node of Ranvier to the next (space between Schwann Cells)
34
What is the diameter and myelination needed for fast conduction?
Large diameter Heavily myelinated
35
What is the diameter and myelination needed for slow conduction?
Small diameter Less myelinated
36
What is divergence?
One axon slplits into many terminal branches
37
What is convergence?
axons from many cells come together | (Heart of integration)
38
What is the function of Glia cells?
* Support cells of NS (pitt crew) * Structure * Transmission (Assist with) * Pathogenesis (Possible role)
39
What are the 3 kinds of macroglia (big support cells)?
1. Astrocytes 2. Oligodendrocytes 3. Schwann Cells
40
What are the functions of Astrocytes?
* Direct role in cell signaling * calcium waves * release glutamate * inc/dec communication between neurons * Scavenger - restor AP * Connect neurons & capillaries (part of blood brain barrier) * Scaffold - Pathway for migrating neurons
41
What are the functions of Oligodendrocytes?
* Protective insulation of the CNS * Insulates several neurons
42
What are the functions of Schwann Cells?
* Myelin of PNS * _one neuron_ → wrapped coverings ("myelinated") * _many neurons_ → simple covering ("unmyelinated") * Phagocytic function in injury: eat cell debris (vacuum cleaner of PNS)
43
What is the function of Microglia?
* Eat cell debris when there is damage in CNS * eats aging neurons * **abnormal activation → may contribute to brain disease**
44
What is Guillain-Barré?
* Auto-immune attack on Schwann cells (peripheral myelin) * weakness and sensory loss * typically myelin regenerates - EXCELLENT recovery
45
What is Multiple Sclerosis?
* Auto-immune attack of oligodendrocytes * signs/symptoms: depneds on location of demyelination * pattern is random * Can get better and worse * inflammation squeezese neurons - fall to sleep - inflammation goes down - function comes back. * typically remyelination does not occur
46
What is the most common tumor of the CNS? What is its most commong location in the brain?
Astrocytoma Frontal lobe (Sx: headache, speech and motor loss, trouble planning, goal setting, organizing)
47
What are three attributes for primitive neural stem cells?
1. Self-renew 2. Differentiate - can change 3. Populate