CH 2: Cartilage And Bone Formation Flashcards
What is responsible for the strength of cartilage? its resilience?
Collagen for sheer strength and water (tissue fluid) for resilience
List the three major components of cartilage matrix.
Collagen water GAG’s
List three locations and three functions for hyaline cartilage.
Hyaline is shiny glass and most common in the human body.
The location is trachea nose bone joints growth plates larynx and rib cage
The function: support cushion and glide intermediate of elastic and fibro
The mature cartilage found in lacuna.
Chondrocyte
Secrete collagen to initiate cartilage formation; analogous to osteoblast
Chondroblasts
Analogous to periosteum
Perichondrium
List two locations into functions very elastic cartilage
Elastic cartilage is the most elastin
Found: the epiglottis and external ear
Function: structure and flexibility
List two locations and two functions for the fibrocartilage
Fibro cartilage is thicker collagen and no perichondrium
the function resists conpression and structure
location: meniscus, vertebral discs, and bone repair.
Which type of cartilage is the strongest
Fibrocartilage
Which type of cartilage lacks a Perichondrium?
Fibrocartilage
Carlos is classified as what type of tissue
Dense irregular connective tissue
Why does cartilage grow and repair itself so slowly
Because it is avascular
No blood supply
Forming bone from soft membrane
Intramembranous ossification
Bone forming from soft tissue but no cartilage.
Found in cranial skull or possibly clavicle
Mesenchymal➡️osteogenic➡️osteoblast➡️bone.
Intramembranous ossification
Future bone composed of hyaline cartilage then converted to bone.
- most bones of the body form by endochondral ossification
- mesenchymal➡️chondroblasts➡️hyaline cartilage➡️osteogenic➡️osteoblasts➡️bone
Endochondral ossification
Steps of Endochondral ossification
- Primary ossification center
- located in the middle of future Bone; diaphysis.
- dying cartilage trigger the penetration of Cartlidge by a blood vessel
- also quick question proceed superficial to deep because it follows the blood vessel - Secondary ossification center
- located inside the emphysis
- ossification proceeds fromdeep too superficial
Nutrients for healthy bones
Vitamins Vitamin c: collagen synthesis Vitamin b12: collagen synthesis Vitamin k: collagen synthesis Vitamin a: increased osteoblasts act Vitamin d: calcification/ca absorption
Any break or crack in bone
Fracture
Simple fracture
Closed, does not break skin
Compound fracture
Open, breaks skin as well as bone
Green stick fracture
One side breaks other side bends common in youth
Comminuted fracture
Fragments at break site, require surgery
Impacted fracture or compression fracture
Two ends of bone driven into each other
Stress fracture
Tiny, often microscopic cracks in bone; painful; overuse injury
Spiral fracture
Ragged break due to twisting force
Epiphyseal fracture
Break at growth plate
Depressed fracture
Broken bone pressed inward
Colles fracture
Common sport injury ( falling while running); radius breaks near wrists; distal portion of radius moves posterior to rest of radius.
Potts fracture
Sole of foot moves inward;lateral
Common ankle; fracture to tibia medially as well as fibula.
Five stages of healing
- Fracture hematoma stage: blood clots at break site
- Procallus stage: broken area becomes vascular
- Fibro cartilaginous stage: fibrocartilage holds broken ends together.
- Bony callus stage: fibrocartilage replaced by spongy bone.
- Remodeling stage:spongy bone slowly becomes compact bone.
Realigning broken end of bone
Reduction t
Open reduction
Surgical
Closed reduction
Non surgical
Epiphyseal plate is ossified on side of diaphysis. Cartilage cells proliferate on side of epiphysis.
Length
Matrix formed around blood vessel on surface bone
Vessel becomes a Haversian canal
Thickness
Pth
Parathyroid hormones
- from parathyroid
- travels through blood
- increases blood ca levels
- pulls ca from the bone by stimulating osteoclast activity
Ct
Calcitonin
- from general thyroid gland
- lowers blood ca levels
- increases ca in bones
- May slow osteoclast activity
- most effective in youth