CH 18:Cancer Flashcards
Two types of tumors
Benign:
-Non-cancerous
-remain in one place
-surgically removed
Malignant:
-Invades/compromises normal organ/tissue function
-Increase in nucleus
3 groups of genes MOST likely to cause cancer
Proto-oncogenes
Tumor suppressor genes
Mutator genes
Common types of cancer
-Carcinomas(Occurs in epithelial tissues)
-Sarcomas(occurs in connective or muscle tissues)
-Gliomas(occurs in nervous tissues)
-Leukemias(Occurs in white blood cells)
Factors that lead to cancer
-Age
-Inherited genes
-Carcinogens
-chemicals
-radiation
-Infectious agents( hepatitis b or c)
-Diet
-Type 2 diabetics
Cells in the immune system do what?
Identify proteins
Immune system does what
defends the body against cancer
2 groups of chemotherapy drugs
Cell cycle specific(CCS)
-Kill cancer and normal cells at specific points
Cell cycle nonspecific(CCNS)
-Kill at any point in cell cycle by adding small molecules at bases of dna
Phases of Cell cycle specific
G1: death of cells
S: disrupts DNA replication
G2: interfere with DNA/ RNA synthesis
Mitosis: prevents chromosomes from separating by poisoning the mitotic spindle
Different chemotherapy options
Adjuvant - chemicals given after surgery or radiation
Neo-adjuvant – chemicals given to shrink a tumor before surgery or radiation
Chemotherapy( kill log) first approach
Late diagnosis
Treatment begins late
Prolongs survivals, but does not prevent death
Chemotherapy( kill log) second approach
Uses combination drug therapy
Begun earlier then 1st approach
Treatments are more frequent
Chemotherapy (kill log) 3rd approach
Early surgery removes primary tumor
Intense chemotherapy for several months
Reduces tumor cells to low number
Can be cured with immune system aid