Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Erin Y3 - Reproduction > Cervical Neoplasia > Flashcards

Cervical Neoplasia Flashcards

1
Q

What is CIN?

A

Cervical intraepithelial neoplasia

Preinvasive phase of squamous cell cervical cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CIN1 (mild)

A

Basal 1/3 of epithelium occupied by abnormal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CIN2 (moderate)

A

Abnormal cells extend to middle 1/3 of epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CIN3 (severe/carcinoma in situ)

A

Abnormal cells occupy full thickness of epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does kolicytosis indicate?

A

HPV infected epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Time scale for progression from HPV to high grade CIN

A

6mnths-3yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Time scale for progression from high grade CIN to invasive cancer

A

5-20yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Risk factors for CIN

A 
More sexual partners
Non-use of barrier contraception
Younger age and first intercourse
Persistence of high risk HPV (16, 18)
Smoking
Immunosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Treatment of CINII/III

A

Large loop excision of the transformational zone (LLETZ)

Ablation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Treatment of CINI

A

No treatment

Cervical screening in 12mnths to see if it’s gone away on its own

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is CGIN?

A

Cervical glandular intraepithelial neoplasia

Preinvasive phase of endocervical adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Risk factors for CGIN

A

Later onset of sexual activity
Smoking
HPV (18)
Higher socioeconomic class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CIN/CGIN is harder to diagnose on smear

A

CGIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the commonest type of cervical cancer?

A

Invasive squamous cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Presentation of cervical cancer

A 
Post-coital bleeding
Intermenstrual bleeding
Post-menopausal bleeding
Brownish or blood stained vaginal discharge
Contact bleeding due to friable epithelium
Pelvic pain
Haematuria/urinary infections
Ureteric obstruction/renal failure
Pelvic mass
Weight loss
Anaemia
Changes in bowel habit
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Investigations for cervical cancer

A

Clinical examination
Colposcopy
MRI: particularly T2, better at depicting local disease
CT/PET: assess lymphatic spread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Spread of cervical cancer

A

Spread to adjacent structures via lymphatics: parametrium, upper vagina, pelvic sidewall, bladder, rectum
Pelvic and para-aortic node metastases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Stage 1 cervical cancer

A

Confined to the cervix

19
Q

Stage 1A cervical cancer

A

Microscopic

20
Q

Stage 1A1 cervical cancer

A

Depth up to 3mm, width up to 7mm

21
Q

Stage 1A2 cervical cancer

A

Depth up to 5mm, width up to 7mm

22
Q

Stage 1B cervical cancer

A

Visible lesion (or >1A2)

23
Q

Stage 2 cervical cancer

A

Spread to adjacent organs

24
Q

Stage 2A cervical cancer

A

Spread to upper 2/3 of the vagina

25
Q

Stage 2B cervical cancer

A

Spread to upper 2/3 of the vagina + parametrial involvement

26
Q

Stage 3 cervical cancer

A

Involvement of the pelvic wall

27
Q

Stage 3A cervical cancer

A

Lower third of vagina

28
Q

Stage 3B cervical cancer

A

Pelvic sidewall and/or hydronephrosis

29
Q

Stage 4 cervical cancer

A

Distant metastases or involvement of rectum or bladder

30
Q

Stage 4A cervical cancer

A

Bladder, rectum

31
Q

Stage 4B cervical cancer

A

Beyond pelvis

32
Q

Treatment for stage 1A cervical cancer

A

LLETZ or cone biopsy

33
Q

Treatment for stage 1A2 cervical cancer

A
  • Simple hysterectomy + pelvic lymphadenectomy

+ve nodes = + adjuvant radiotherapy

34
Q

Treatment for stage 1B cervical cancer

A

Radical hysterectomy + pelvic lymphadenectomy
or
Chemotherapy (cisplatin, caroboplatin/paclitaxol) and radiotherapy

35
Q

Treatment for stage 2-4 cervical cancer

A

Chemotherapy

36
Q

Treatment for cervical cancer recurrence

A

Most are suitable for palliative care only

37
Q

When are patients invited for cervical screening?

A

Women aged 25-49 invited every 3 years

Women aged 50-64 invited every 5 years

38
Q

Patients with __ are screened annually

A

HIV

other certain groups of immunocompromised patients may have additional screening

39
Q

Negative smear recall time and colposcopy referral

A

5yrs regardless of age

No colposcopy

40
Q

HPV positive and negative cytology smear recall time and colposcopy referral

A

1yr

Colposcopy: only if 3 consecutive samples are virology positive

41
Q

HPV positive and positive cytology (low grade, borderline) smear recall time and colposcopy referral

A

Colposcopy within 8wks

42
Q

HPV positive and positive cytology (high grade) smear recall time and colposcopy referral

A

Colposcopy within 4wks

43
Q

HPV positive and glandular abnormality smear recall time and colposcopy referral

A

Colposcopy within 2wks

44
Q

Smear with suspicion of invasion recall time and colposcopy referral

A

Colposcopy immediately/within 2wks

Erin Y3 - Reproduction (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions