Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Y2S2 - Cell Signalling > CellSig7 - 15 > Flashcards

CellSig7 - 15 Flashcards

1
Q

What do many GPCR activate?

A

PI - increasing the activity of phospholipase C-b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do many RTK activate?

A

Phospholipase C-g and PI3-kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does phospholipase C-b catalyse the production of?

A

Inositol trisphosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does phospholipase C-g catalyse the production of?

A

Diacylglycerol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does PI stand for?

A

Phosphotidyl inositol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Outline a PI pathway

A

GPCR activation > Gq activation > phospholipase C-b activation > separation of PIP2 and IP3 > IP3 gated Ca release > activation of PKC/PIP2 complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What can phospholipase A2 do?

A

Generate arachadonic acid (AA) from hydrolysis of PIP2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is AA?

A

Arachadonic acid - precursor for hormone i.e. prostaglandins, leukotrienes and thromboxanes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is PIP2?

A

PI(4,5)P2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does diaglycerol do?

A

Activates PKC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is DAG?

A

Diaglycerol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What can diacylglycerol kinase (DGK) do?

A

Phosphorylate DAG to form phosphatidic acid (precursor of PI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What links PI-3-kinase to tyrosine phosphorylate transmembrane receptors?

A

P85 in the SH2 and SH3 domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does PTEN stand for?

A

Phosphatase and tensin homologue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is PTEN?

A

Tumour supressor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Y2S2 - Cell Signalling (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions