Cells and Organs Of The Immune System Flashcards
Two types of T helper cells:
TH1 cells help the CD8+pre-cytotoxic cells.
TH2 cells help B cells
Two major lineages:
Myeloid precursor and lymphoid precursor
Type of the immune system responsible for the maturation of antigen-reactive cells.
Primary response
Type of immune system responsible for antigen contact and response
Secondary response
Two main type of tissue that disposes worn-out bloodness
Red pulp
Two main type of tissue that contains the lymphoid tissue
White pulp
Large white cells that can engulf and digest marauding microorganism and other antigenic particles. Some have the ability to present antigen to lymphocytes
Phagocytes
Important phagocytes
Monocyte and macrophage
Other antigen-presenting cells;
B cells, macrophage, type 1 & 2 dendritic cells
Irregularly shoed wbc. Have long threadlike tentacles that enmesh lymphocytes and antigens. Can be found in spleen.
Dendritic cells
These are dendritic cells that travel in the skin, picking up antigen and transporting it to lymph nodes. Found in pancreas
Langerhans cells
They play a key role in acute inflammatory response
Neutrophils
It is a noncirculating counterpart of the basophil. Located in the lungs, skin, tongue, and linings of the nose and intestinal tract. Responsible for the symptoms of allergy.
Mast cell
F: SRBC receptor, t cell adhesion/ activation
CD2
Signal transduction
CD3
Co-recognition of MHC class 2 with TCR, primary receptor of HIV retrovirus
CD4
Involved in signaling through TCR and BCR
CD5
Involved in T cell proliferation, cell adhesion
CD6
Co-recognition of MHC class 1 with TCR
CD8
Regulation of B cell growth and proliferation
CD10
Granulocytes neutrophil only
CD16b
Receptor for LPS and LBS
CD14
Mediates signal transduction on NK cells
CD16a
Signals transduction regulating B cell responsiveness
CD19
Involved in B cell proliferation/activation, part of the signal transduction complex
CD21
Regulates IgE synthesis, mediates cytotoxicity by macrophage and eosinophil
CD23
Involved in T cell and C cell activation/proliferation
CD27
T cell co-stimulatory signal
CD28
Regulatory B cell
CD32
Negative regulatory role in myeloid hematopoiesis. Important in distinguishing myeloid from lymphoid leukemia.
CD33
Stem cell marker, adhesion
CD34
Maintains adherence of C4b/C3d- coated particles for phagocytosis
CD35
Involved in B cell differentiation, promotes macrophage cytokine production.
CD40
Central role of platelet activation/proliferation
CD41
Required for T and B cell antigen receptor mediated activation/tyrosine phosphatase
CD45
Mediated homophilic adhesion
CD56
Phagocytosis, involved in antigen capture, antibody-dependent cellular cytotoxity
CD64
Inhibits phagocytosis
CD65s
Involved in B cell activation/proliferation
CD72
Transmit signals into cytoplasm on antigen binding to surface Igs
CD79
Involved in extravasation of leukocyte
CD87
Induces phagocytosis, degranulation, respiratory burst, killing of microorganism
CD89
Mediator of phagocytosis
CD91
Regulator for megakaryocyte and platelet formation, prevention of apoptosis
CD110
Growth factor receptor
CD117
Signaling for IL-2,4,7,9,15
CD132