Cell Signalling 1&2

Question 1

What does MAPK stand for

Answer 1

Mitogen activated protein kinase

Question 2

What is the three kinase cascade model

Answer 2

MAPKKK -> MAPKK -> MAPK -> Substrate

Question 3

What are the three MAPK pathways in mammals

Answer 3

stimulus to G protein receptor
growth factors and ras
cytokines or stress and rho

Question 4

what are the 4 types of regulatory motifs in signalling

Answer 4

1. feedback loops
2. branching
3. convergance
4. crosstalk

Question 5

What is the role of feedback loops in signalling

Answer 5

for timing and fine tuning

Question 6

What is the role of branching in signalling

Answer 6

distribution and diversification

Question 7

what is the role of convergence in signalling

Answer 7

integration and timing

Question 8

What is the function of cross talk in signalling

Answer 8

Integration, timing and fine tuning

Question 9

What are the 4 cell fates

Answer 9

1. rest (quiescence)
2. proliferation
3. differentation
4. apoptosis

Question 10

What is G1

Answer 10

Gap 1 in cell division
- quinescent cells stay here
- normal cell metabolism