Cell recognition and the immune system Flashcards
Pathogen
Infectious organisms which spread communicable diseases are known as pathogens
Pathogens include bacteria, viruses, fungi and protoctista: the type of pathogen determines how it spreads
Vector
A vector is something which carries a pathogen from one organism to another
Antigen
Antigens are molecules present on the surface of cells, which trigger an immune response
The effect of antigen variability on disease and disease prevention
Reduces the effectiveness of vaccines
Antigenic drift/Antigenic shift
Antibodies are no longer complementary to antigens/don’t bind
Phagocytosis
- Chemotaxis - phagocyte attracted to pathogen by chemical products (toxins) from the pathogen. Moves towards pathogen along concentration gradient
- Phagocyte has several receptors on cell surface membrane that attach to chemicals on the surface of the pathogen
- Lysosomes move towards the phagosome being formed (an engulfed pathogen forms a vesicle called a phagosome) as the phagocyte engulfs the pathogen
- Hydrolysis - the Lysosomes release lysozyme’s into the phagosome, where they hydrolyse the pathogen
- The Hydrolysis products are absorbed by phagocyte
Describe the response of T lymphocytes to a foreign antigen
1) Pathogens are taken in by phagocytes after invading body cells.
2) The phagocyte places antigens from the pathogen on its cell-surface membrane.
3) Receptors on the specific helper T cell fit exactly onto these antigens.
4) This attachment activates the T cell to divide rapidly by mitosis and form a clone of genetically identical cells.
The cloned T cells:
a) develop into memory cells that enable a rapid response to future infections by the same pathogen.
b) stimulate phagocytes to engulf pathogens by phagocytosis.
c) stimulate B cells to divide and secrete their antibody.
d) activate cytotoxic T cells.
The role of antigen-presenting cells in the cellular response
An APC presents antigens to helper T cells to activate the T cells during a cellular response
The role of helper T cells (TH cells) in stimulating cytotoxic T cells (TC cells), B cells and phagocytes
Helper T cells attach to phagocyte which activates it to clone by mitosis
The cloned T cells activate cytotoxic T cells, stimulate B cells to divide and secrete their antibody and stimulate phagocytes to engulf pathogens by phagocytosis
Antibody
Antibodies are proteins with specific binding sites synthesised by B cells
Antibody structure
Made up of 4 polypeptide chains
The chains of one pair are long and are called heavy chains, while the chains of the other pair are shorter and are light chains
Each antibody has a specific binding site that fits exactly onto a specific antigen to form an antigen-antibody complex
The binding site is different on different antibodies and is called the variable region - consists of a sequence of amino acids that forms a specific 3D shape that binds directly to a specific antigen
The rest of the antibody is the constant region which binds to receptors on B cells
The formation of an antigen-antibody complex, leading to the destruction of the antigen, limited to agglutination and phagocytosis of bacterial cells
Once made, antibodies function by:
Binding to antigen on pathogen and acting as a marker/opsonin, making the entire antibody pathogen complex more likely to be phagocytosis than the pathogen alone would be
Binding to antigen on multiple pathogens and clumping pathogens together (agglutination), again making pathogens easier to phagocytose
The roles of plasma cells and of memory cells in producing primary and secondary immune responses
When a person is initially exposed to an antigen, the immune response occurs to produce plasma cells (which produce antibodies) to destroy the antigen
This is called the primary response
The primary response generates memory cells, so that if the same antigen is encountered again, the memory cells will rapidly produce many antibodies to destroy the antigen
This is called the secondary response and:
1. Is faster -> antibodies more produced after a short period of time after infection
2. Leads to antibodies being produced more quickly after they start being produced
3. Leads to a greater total number of antibodies being produced
As such the pathogen is destroyed before symptoms develop
Memory cells can circulate in the blood stream for years of they provide long-term immunity from the original infection -> this is natural, active immunity
The use of vaccines to provide protection for individuals and populations against disease
If a person is artificially exposed to an antigen (in a vaccine) the immune response is simulated and thus the response of memory cells so then if the person is exposed to the antigen in future they will become immune to it
Artificial, active immunity
1. Vaccine contains antigens from pathogen
2. Macrophage carries out phagocytosis of antigen, then displays antigen on its surface, acting as an antigen presenting cell
3. Specific T helper cell with complementary receptor will bind to protein and stimulates specific B cell
4. B cell divides by mitosis then differentiates to form plasma cells and memory cells
5. Plasma cells produce and secrete antibodies with binding site complementary to antigen
Vaccination is particularly useful for highly pathogenic disease which may cause a lot of damage/death if contracted
Usually made of dead or attenuated pathogens or isolated antigen proteins from their surface
Herd immunity
A pathogen must be passed from host to host to survive in the population
If the majority of the population are immune to a pathogen, it cannot spread, meaning the whole population is protected, even including those who are not yet vaccinated
The proportion of the population who need to be vaccinated to achieve herd immunity varies from pathogen to pathogen (depending how quick it is to spread)
The differences between active and passive immunity
- Active involves memory cells, passive does not
- Active involves production of antibody by plasma cells/memory cells
- Passive involves antibody introduced into body from outside/named source
- Active long term, because antibody produced in response to antigen
- Passive short term, because antibody (given) is broken down
- Active (can) take time to develop/work, passive is fast acting