Cell Physiology Flashcards

1
Q

What is the basic fundamental units of animal life?

A

Cells

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2
Q

True or False: Ions are called electrolytes because they are able to conduct an electrical current in solution.

A

True

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3
Q

Give examples of a cation and an anion (1 each) found in body fluids.

A
Cation = Na^+ , K^+ , Ca^2+ , Mg^2+ , etc.
Anion = Cl^- , I^- , OH^- , etc.
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4
Q

How is the acidity or alkalinity of a fluid determined? (NOT by using the pH scale.)

A

The concentration oh H+ relative to concentration of OH-

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5
Q

Describe the pH scale.

A

0 - 14: 7 = neutral, less than 7 = acidic (more H+) and greater than 7 = basic (more OH-)

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6
Q

Where is interstitial fluid found?

A

Between cells but outside of blood vessels.

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7
Q

Define selectively permeable (as pertaining to cell membranes).

A

Impermeable to some substances & freely permeable to others.

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8
Q

What 3 factors detemine whether or not molecules may pass into or out of cells by passive diffusion?

A

Molecule size, lipid solubility, and ionic charge.

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9
Q

Briefly explain how negative (less positive) charge inside of cells is maintained.

A

K+ diffuses out of cells more easily than Na+ goes back into cells via simple diffusion. Sodium-potassium only retrieves 2 K+ for every Na+ pumped out per ATP molecule used. Cytosolic proteins have slight negative charge.

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10
Q

Which of the following are all examples of passive transport processes?

a) diffusion, facilitated diffusion, exocytosis
b) diffusion, filtration, osmosis
c) facilitated diffusion, filtration, endocytosis
d) filtration, exocytosis, osmosis

A

b) diffusion, filtration, osmosis

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11
Q

What differentiates a passive membrane process from an active one?

A

Active processes require ATP; passive processes do not need energy to function.

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12
Q

List one passive membrane process and one active membrane process.

A
Passive = simple diffusion, facilitated diffusion, osmosis, filtration.
Active = active transport, endocytosis (phagocytosis, pinocytosis), exocytosis
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13
Q

What is Intracellular fluid ( ICF ) ?

A

Water inside the cell.

Most of water in body.

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14
Q

What is Extracellular fluid ( ECF ) ?

A

Outside the cell.

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15
Q

Intravascular & lymphatic?

A

inside blood & lymphatic vessels.

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16
Q

Interstitial?

A

in tissues but outside of the vasculature.

17
Q

What is more than one ion together called?

A

ionic compound.

Ex: salt = composed of oppositely charged ions that separate when mixed in water.

18
Q

What are acids & bases?

A
Acids = release hydrogen ions (H+)
Bases = release hydroxyl ions (OH-)
19
Q

What is the flow of fluid and nutrients into and out of called regulated by?

A

Plasma membrane

20
Q

What is Diffusion?

A

Kinetic energy - increases w/ higher temp
Movement from a higher to lower concentration - concentration gradient

Size - small molecules like H2O pass easily
Lipid solubility - dissolved gases, alcohols, steroids easily pass through cell’s lipid bilayer
Charged ions - specialized protein pores called channels selectively let certain ions pass

21
Q

Explain Facilitated Diffusion

A

Movement of some larger and/or nonsoluble molecules with the asst. of a protein carrier located in lipid bilayer

Binding of the extracellular molecule to membrane protein causes protein to change shape & allow molecule to pass into cell.

Glucose is too large to rely on simple diffusion so it must enter cell via a protein carrier.

Protein is limited by number of carrier proteins available for binding.

22
Q

What is osmosis?

A

passive movement of water through a semipermeable membrane from a dilute to a more concentrated environment.

Occurs to achieve same concentration of solution on both sides of the membrane = concentration equilibrium.

Force moving water across the membrane = osmotic pressure.

23
Q

What is Concentration Gradient?

A

same concentration of solution on both sides of the membrane.

24
Q

What is Osmotic Pressure?

A

force of moving water across the membrane.

25
What is ISOtonic ?
ECF has SAME concentration of dissolved substances as ICF
26
what is HYPOtonic ?
ECF less concentrated than ICF -> water into cell -> cell SWELLS
27
what is HYPERtonic ?
ECF more concentrated than cytoplasm -> water into ECF -> cell SHRINKS
28
what is ONCOTIC PRESSURE ?
difference between the osmotic pressure of blood & that of interstitial fluid or lymph = force, w/ plasma proteins (pp), keeping fluid in blood vessels. *leaky vessels EX: diseases causing decrease in pp -> decrease in ONCOTIC PRESSURE -> leakage of fluid of vessels & into the interstitium or body cavities. (causes EDEMA)
29
When is energy ATP required to transport molecules?
When they are: not lipid soluble too large on wrong side of the pressure gradient
30
explain ACTIVE TRANSPORT
Some amino acids & ions needed Relies on a carrier protein with a specific binding site, but doesnt require a concentration gradient ALL cells participate in active transport of electrolytes Na+ , K+ , Ca2+ , Mg2+ and specialized cells can transport Cl- , I- , and Fe2+
31
Whats involved in cytosis?
``` Active transport (requires energy) Endocytosis = going INTO cell -Phagocytosis -Pinocytosis -Receptor mediated Exocytosis = going OUT OF cell ```
32
explain ENDOCYTOSIS
Enables large particles, liquids and entire cells to be taken into cell by engulfing Phagocytosis - engulfs solid material forming a PHAGOSOME Pinocytosis - engulfs liquid forming PINOCYTIC VESICLE Receptor-mediated - very selective. occurs in cells w/ specific protein receptor sites in their cell membranes for binding of ligands like hormones, iron, & cholesterol -> taken into cell forming vesicle called a COATED PIT
33
explain EXOCYTOSIS
Substances to be exported out of cells are packaged in vesicles in the ER & GOLGI body & moved through CYTOPLASM -> vesicles fuse w/ plasma membrane & release contents from intracellular environment into the ECF EXCRETION - EXOcytosis of waste products SECRETION - EXOcytosis of manufactured molecules (neurotransmitters, hormones, mucus, histamine, etc.)
34
what is MEMBRANE POTENTIAL?
the difference in permeability of plasma membrane leads to changes in the distribution of the charged particles on either side forming a VOLTAGE which = POTENTIAL ELECTRICAL ENERGY CREATED BY THE SEPARATION OF OPPOSITE CHARGES.
35
RESTING Membrane Potential
outside of cell is slightly more positive than inside of cell, mostly due to Na+ & K+ ions Both passive and active processes work to place more + ions on outside & keep inside of cell negatively charged. More K+ inside cell that diffuses out, while Na+ more concentrated outside but cant enter cell easily, so INFLUX OF Na+ IS LOWER THAN THE OUTFLOW OF K+ via DIFFUSION. For every cycle of active transport, have 3 Na+ out for every 2 K+ retrieved. Also, cytoplasmic proteins tend to be negatively charged.
36
What are the two categories based on the way cells divide?
Meiosis - reproductive cells divide Mitosis - somatic cells divide ability to grow & repair tissue based on division of somatic cells.
37
What are the two phases of MITOSIS?
Interphase - period between cell divisions - "metabolic" phase when cell is growing, maturing & differentiating and Mitotic Phase - cell is actively dividing; divides into 2 identical daughter cells.
38
Explain 3 stages of Interphase.
``` Growth 1 (G1) Phase - intense metabolic activity & cellular growth -> cell doubles in size Synthetic (S) Phase - DNA synthesis & replication Growth 2 (G2) Phase - synthesis of enzymes &proteins needed for cell division & continued growth ```
39
Explain 4 stages of the Mitotic Phase.
PROPHASE - chromosomes & mitotic spindle form; disintegration of nuclear envelope. METAPHASE - chromosomes line up in EQUATER (exact center) of spindle & cytoplasm begins to form METAPHASE PLATE ANAPHASE - chromosomes split & take on V form; cell elongates & cytoplasm begins to constrict TELOPHASE - chromosomes unravel, elongate & return to diffuse thread-like form (chromatin); nuclear envelope forms around each new set of chromosomes; spindle disassembles; cytoplasm divides (cytokinesis) marking end of mitosis.