Cell Membranes And Transport Flashcards
What is the function of the cell membrane?
Controls the exchange of the materials such as nutrients and waste products between the cell and it’s environment, so acts as a selective barrier.
For communication between cells, by cell signaling. For example, they enable cells to receive hormone messages.
Separate cell components from the outside environment which is known as compartmentalisation.
Allows recognition of other external substances such as antigen.
Allows mobility in some organisms, e.g amoeba.
What is the thickness of the cell membrane
These cell membrane is about 7nm thick, made of phospholipid bilayer.
Why is the cell surface membrane illustrated as a fluid mosaic model?
Fluid: because both the phospholipids and proteins can move about by diffusion within their own monolayers. Some protein molecules can move also within the phospholipid bilayer.
Mosaic: describes the pattern produced by the scattered protein/glycoprotein molecules when the surface of the membrane is viewed from above.
What are the factors affecting the fluidity of the cell membrane?
Some of the phospholipid tails are saturated and some are unsaturated. The more unsaturated they are, the more fluid the membrane. This is because the unsaturated fatty acid tails are bent and therefore fit together more loosely.
Fluidity is affected by the length of the phospholipid tail: the longer the tail the less fluid the membrane.
Temperature: The lower temperature the less fluidity of the membrane.
How do some organisms which cannot regulate their own temperature use the fluidity of the cell membrane to survive in cold temperatures?
Some organisms which cannot regulate their own temperature, such as bacteria and yeasts, respond by increasing the proportion of unsaturated fatty acids in their membranes. The increased fluidity means the cells can survive colder temperatures.
Which biomolecules exist in the membrane structure.
Lipids:
1.Phospholipids
2.glycolipids
3.cholesterol
Protein
1.protein
Carbohydrates:
1.glycolipids
2.glycoproteins
Describe the structure of phospholipids
The basic structure of a cell membrane is phospholipid bilayer
The hydrophilic phosphate heads face outwards into the aqueous environment outside the cell.
Phosphate heads may contain a fatty substance known as choline.
The hydrocarbon tails of fatty acid face in words and create a hydrophobic interior.
What are the functions of the phospholipids tails?
The tails are non-polar, so it is difficult for most polar molecules or ions to pass through membranes as they act as a barrier against water soluble molecules such as sugars amino acids and proteins.
Phospholipid tails maintain fluidity of the cell membrane which allows it to stretch under pressure and to reseal itself if it is disrupted as in cytosis.
How do phospholipids function as signalling molecules.
Some phospholipids can be modified chemically to act as signalling molecules. For example they move about in the phospholipids bilayer and activate other molecules such as enzymes.
Alternatively they may be hydrolysed to release small water soluble, glycerol-related molecules and these diffuse through the cytoplasm and bind to specific receptors. This system releases Ca ions from ER to cause exocytosis of digestive enzymes in pancreatic cells.
Describe the structure of cholesterol
A cholesterol molecule has a hydrophilic head and a hydrophobic tail and fits neatly between phospholipid molecules.
It is made of four linked hydrocarbon rings.
Animal cell membrane has as much cholesterol as phospholipids.
Cholesterol is less common in plant cell membrane and absent from most prokaryotes.
What are the functions of cholesterol
Regulates Fluidity
Provides mechanical stability
Controls the exchange of molecules across the membrane
How does cholesterol regulate fluidity?
At low temperature cholesterol increases the fluidity of the membrane to prevent it from becoming too rigid. This is because it prevents close packing of phospholipid tails.
Interaction between phospholipid and cholesterol molecules also helps to stabilize cells at higher temperatures when the membrane becomes otherwise too fluid.
How does cholesterol provide the cell membrane with mechanical stability?
Without cholestrol molecules the cell membrane could break and the cell could burst open.
Cholesterol control the exchange of molecules across the membrane ❓
As the hydrophobic regions of cholesterol molecules help to prevent ions and polar molecules from passing through the membrane. This is particularly important in the myelin sheath (made up of many layers of cell surface membrane) around the nerve cells, where leakage of ions would slow down nerve impulses.
What are the two protein structures?
Proteins may be intrinsic or extrinsic proteins.
Describe intrinsic (integral) proteins.
Proteins that are found inbedded within the membrane are called intrinsic proteins or integral proteins. Intrinsic proteins may be found in the inner layer, the outer layer or most commonly commonly spanning the whole membrane in which case they are known as trans membrane proteins.
What are the hydrophobic regions which cross the membrane in transmembrane proteins made up of?
In trans membrane protein the hydrophobic region which cross the membrane is often made up of one or more alpha – helix chains.
How does intrinsic proteins help form the fluid mosaic model?
Some intrinsic proteins are fixed in the membrane while others are floating and moving forming the fluid mosaic model.
How are intrinsic proteins arranged ❓
Are arranged with their hydrophilic parts (R groups of amino acids) of their chains on the outer surface of the membrane, while hydrophobic parts embedded within the membrane among hydrophobic tales of phospholipids.
The hydrophilic parts of protein are repelled by hydrophobic interior of the membrane, and therefore face into the aqueous environment inside or outside of the cell or line hydrophilic pores which pass through the membrane.
Describe extrinsic (peripheral) proteins:
These are found on the inner or outer surface of the membrane. Extrinsic proteins might be bound to intrinsic proteins phospholipids or other molecules in the cell.
What are the functions of channel proteins and carrier proteins in a membrane?
They are involved in the selective transport of polar molecules and ions across the membrane. Many proteins act as transfer proteins as they provide hydrophillic channels for passageways for ions or polar molecules.
What is the function of enzymes in a membrane
Some membrane proteins are enzymes, for example the digestive enzymes found in the cell surface membrane of the cells lining the small intestine. These catalyze the hydrolysis of molecules such as disaccharides.
How do proteins in the cell membrane function as energy transfer.
Proteins present on the membrane of chloroplast and mitochondria are involved in the process of photosynthesis and respiration respectively.
How do proteins function as cell-shape proteins?
Some proteins on the inside of the cell surface membrane are attached to a system of protein filaments inside the cell, known as the cytoskeleton. These proteins help to maintain and decide the shape of the cell. They may also be involved in changes of the cell shape when cells move.
What are the three different functions of receptor proteins?
Signaling receptors
Endocytosis receptors
Cell adhesion receptors
List the functions of proteins found in the membrane
Channel proteins or carrier proteins
Enzymes
Energy transfer
Cell shape proteins
Receptor proteins
Explain how signaling receptor proteins function.
Proteins have very specific shapes. This makes them ideal as receptor molecules for chemical signaling between cells. For example, hormones are chemical messengers only binding to specific target cells which have the correct receptor sites, e.g. glucagon receptors in the liver cell. Cells that do not have glucagon receptors are not affected by glucagon. Another example is neurotransmitters that are chemicals that cross synapses allowing nerve impulses to pass from one cell to another.
What is the function of receptor molecules?
The carbohydrate chain helps glycoproteins and glycolipids to act as receptor molecules. The function of receptor molecules is to bind with particular substances at the cell surface membrane. Different cells have different receptors depending on their function.
How do proteins function as endocytosis receptors?
Proteins bind to molecules that are part of the structure to be engulfed by the cell surface membrane.
How do proteins function as cell adhesion receptors?
Proteins are involved in binding cells to other cells and tissues and organs of animals.
Describe the structure of carbohydrate molecules in the cell surface membrane.
Some proteins and lipids have short branching carbohydrate chains like antennae (glycocalyx) forming glycoproteins and glycolipids respectively. Both are found on the external surface of the membrane only. In animal cells the glycocalyx formed mainly from glycoprotein while in plant cells it is formed mainly in glycolipids.
What are the functions of carbohydrates in cell membrane?
Stabilize membrane structure
Act as receptor molecules
Involved in cell-cell recognition and cell attachment
Are antigens
Explain how carbohydrates help to stabilize the membrane?
Carbohydrates project out into the water fluid surrounding the cell where they form hydrogen bonds with water molecules and so help stabilize the membrane structure.
Explain how carbohydrates function as receptor molecules?
Carbohydrates also act as receptor molecules for chemical signals by binding with particular substances such as hormones or neurotransmitters.
Explain how carbohydrates can function in cell attachment or adhesion.
Glycolipids also have branching carbohydrate side chains and are involved in cell to cell recognition. Glycoproteins are also involved in sticking the correct cells together in tissues (cell attachment or adhesion)
Explain how carbohydrates function in cell to cell recognition?
One group of glycoproteins known as antigens are important in allowing cells to recognize each other each type of cell has its own type of antigen.
What is the difference in units of thickness in which the cell wall and cell membrane are normally measured in?
Cell wall is measured in micrometers. (0.2)
Cell membrane is measured in nanometers. (7)
What is the difference in location of the cell wall in the cell membrane?
Cell wall surround some cells but not all cells such as not animal cells and it only surrounds sounds whereas the cell membrane surrounds all cells and can be found inside the cells.
What is the difference in the permeability of the cell membrane and the cell wall?
These cell wells is freely permeable whereas the cell membrane is partially / selectively permeable.
What is the function and stiffness of the cell wall and cell membrane
The function of the cell wall is to provide mechanical strength whereas the function of the cell membranes to act as a selective barrier. The cell wall is rigid whereas the cell membrane is fluid.
Explain the importance of exchange materials between cell and their environments.
- Two obtain nutrients such as glucose or other useful materials such as oxygen for respiration.
- To excrete waste substances such as carbon dioxide from respiration.
- To secrete useful materials such as hormones and enzymes
- To generate ionic gradients essential for nervous and muscular activity.
To maintain a stable pH and ionic concentration within the cell for enzyme activity.
Define diffusion
Diffusion is the net movement of molecules or ions of a substance from a region of high concentration to a region of its lower concentration down a concentration gradient, due to random motion of ions and molecules caused by the natural kinetic energy of molecules or ions. This includes the diffusion of small non-polar molecules (such as oxygen and carbon dioxide) through the plasma membrane, as well as diffusion of fat-soluble molecules (such as vitamin A) through the plasma membrane.
Is diffusion a passive or active process?
Diffusion is a passive process in which molecules or ions tend to reach an equilibrium situation, where they are evenly spread in each volume of space.
What are the factors affecting the rate of diffusion?
The steepness of the concentration gradient
Temperature
The surface area
The nature of a molecules
The distance