cell mediated response Flashcards
what types of cells are involved in cell mediated response
T lymphocytes
what do T cells mature ?
thymus
is the cell mediated response specific ?
yes
what are antigen presenting cells (APC) ?
any cells that present a non self antigen on their surface
why is it called cell mediated ?
T cells only respond to antigens which are presented APC cells
what is step one of the cell mediated response?
once the pathogen has been engulfed and destroyed by the phagocyte , the antigens will be placed on the cell surface so phagocyte is now a antigen presenting cell
what is step 2 of the cell mediated response ?
helper t cells have receptors on their surface that can attach to the antigen presenting cell
what is step 3 of the cell mediated response ?
once attached this activates the helper T cells to divide by mitosis to replicate and make large number of clones
what is step 4 of the cell mediated response ?
cloned help T cells differentiate into different cells .
what can helper T cells differentiate into ?
some remain as T helper cells and activate B lymphocytes.
some stimulate macrophages to perform more phagocytosis
some become memory cells for that shaped antigen
some become cytotoxic killer cells
what can cytotoxic T cells destroy ?
abnormal or infected cells
how do cytotoxic T cells work ?
produce perforin ,an protein , which makes a pore so any substance can enter or leave a cell.This causes cell death
where is a cytotoxic T cell most likley to act ?
most common in viral infects because viruses infect body cells.body cells are sacrificed to prevent viral replication .