cell mediated response Flashcards

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1
Q

what are lymphocytes

A

-Lymphocytes are white blood cell involved in the specific immune response

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2
Q

Where do t-lymphocytes mature

A

-T-lymphocytes mature in the Thymus but made in the bone marrow

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3
Q

What is a APC

A

—Antigen presenting cell that presents a non-self antigen on its surface :
•infected body cells
•a phagocyte which has engulfed and destroyed a pathogen
•cells from transplanted organs
•cancer cells

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4
Q

What are the steps in cell meditated response

A
  1. Once a pathogen has been engulfed and destroyed by a phagocyte, the antigens are positioned on the cell surface.This is now called an (APC)
  2. Helper T cells have receptors on their surface which can attach to the antigens on APC.
  3. Once attached this activates the helper T cells to divide by mitosis to replicate and make large of clones
  4. Cloned helper T cells differentiate into different cells:
    •Some remain as helper T cells and activate B lymphocytes
    •Some stimulate phagocyte to perform more phagocytosis
    •Some become memory cells for that shaped antigen
    •Some become cytotoxic T cells (killer T cells)
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5
Q

What are cytotoxic t cells

A

Cytotoxic T cells destroy abnormal or infected cells.
They release a protein, perforin, which embeds in the cell surface membrane and makes a pore (a hole) so that any substances can enter or leave the cell.
This causes the cell death.

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